A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.

Scientific Reports
Hisashi MoriguchiChifumi Sato

Abstract

Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs).

References

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Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shin-ichi FukumotoHiroyuki Aburatani
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Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Oriol GallegoXavier Parés
Nov 26, 2008·Chemico-biological Interactions·Ganesaratnam K BalendiranEdmund Maser
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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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