Jul 13, 2019

A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation

Dementia and Neurocognitive Disorders
Seung Hyun KimK-ARPI

Abstract

Alzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects has hindered the development of effective therapeutic agents. Research plans that integrate new drug discoveries are urgently needed, including those based on novel and reliable biomarkers that reflect not only clinical phenotype, but also genetic and neuroimaging information. Therapeutic strategies such as stratification (i.e., subgrouping of patients having similar clinical characteristics or genetic background) and personalized medicine could be set as new directions for developing effective drugs for AD. In this review, we describe a therapeutic strategy that is based on immune-inflammation modulation for a subgroup of AD and related dementias, arguing that the use of stratification and personalized medicine is a promising way to achieve targeted medicine. The Korean AD Research Platform Initiative based on Immune-Inflammatory biomarkers (K-ARPI) has recently launched a strategy to develop novel biomarkers to identify a subpopulation of patients with AD and to develop new drug candidates for delaying the progression of AD by modulati...Continue Reading

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Mentioned in this Paper

Biological Markers
Immune Response
Research
Nap1 protein, mouse
Cell Motility
Stratification
Sphingosine kinase-1
Myeloid Cells
Alzheimer's Disease
TREM2

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