A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Hui-Yuan HouYan Cai

Abstract

Choroidal neovascularization (CNV) is a common cause of severe and irreversible visual loss; however, the treatment of CNV has been hindered by its complex and poorly understood pathogenesis. It has been postulated that bone marrow (BM)-derived cells (BMCs) contribute to CNV, but little is known about the role of mesenchymal stem cells (MSCs) in CNV and their therapeutic potential for CNV treatment. We found that BM-derived MSCs transplanted by intravenous injection into laser-induced CNV mouse models were specifically recruited into CNV lesions, where they differentiated into multiple cell types and participated in the development of neovascularization, without stagnation in other organs. By taking advantage of this recruitment potential, engineered MSCs were used to produce the antiangiogenic pigment epithelial-derived factor (PEDF) at the CNV sites, thereby inhibiting the growth of CNVs and stimulating regressive features. Further studies indicated that the effect may be mediated, at least partly, by retinal pigment epithelial (RPE) cells, which function as important regulators for CNV development. These results suggest that MSCs contribute to CNV and could serve as delivery vehicles of antiangiogenic agents for the treatmen...Continue Reading

References

Apr 2, 1999·Science·M F PittengerD R Marshak
Jun 26, 2001·Journal of Cellular Physiology·K MoriP A Campochiaro
Sep 12, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yu-Sheng WangPeter Wiedemann
May 15, 2003·Survey of Ophthalmology·Jayakrishna AmbatiAnthony P Adamis
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Nilanjana SenguptaMaria B Grant
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Diego G Espinosa-HeidmannScott W Cousins
Dec 23, 2003·Stem Cells·Minoru TomitaSusumu Ikehara
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Jun 29, 2004·Biochemical and Biophysical Research Communications·Hidenori TakahashiMasataka Sata
Aug 11, 2004·Progress in Retinal and Eye Research·Colin J Barnstable, Joyce Tombran-Tink
Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Rajendra S ApteThomas A Ferguson
Dec 21, 2005·Experimental Eye Research·S Patricia Becerra
Jan 3, 2006·American Journal of Ophthalmology·Richard F Spaide
Jan 18, 2006·Clinical Biochemistry·Jian-Ping Tong, Yu-Feng Yao
Oct 13, 2006·The Journal of Biological Chemistry·Luigi NotariS Patricia Becerra
Mar 21, 2007·Journal of Cellular and Molecular Medicine·Denitsa DochevaMatthias Schieker
May 8, 2007·Blood·Martin BreitbachBernd K Fleischmann
May 25, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raquel Lima e SilvaPeter A Campochiaro
Jun 26, 2007·Microvascular Research·A AfzalM B Grant
Aug 7, 2007·International Journal of Hematology·Brett HallFrank Marini
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Stephen G BallCay M Kielty
Feb 6, 2008·Journal of Autoimmunity·Keiya OzawaAkihiro Kume
Mar 19, 2008·Journal of Cellular Biochemistry·Harshini SarojiniEugenia Wang
Apr 1, 2008·Journal of Cellular and Molecular Medicine·Andrea MohrRalf Zwacka
Jul 16, 2008·Progress in Retinal and Eye Research·Salvatore Grisanti, Olcay Tatar

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Citations

Apr 13, 2011·Human Gene Therapy·J Timothy Stout, Peter J Francis
May 13, 2011·Stem Cells and Development·Tajinder SinghAkshay Anand
Jun 8, 2012·Journal of Biomedicine & Biotechnology·Mina ElahyCrispin R Dass
Jun 12, 2012·Journal of Biomedicine & Biotechnology·Jung-Tung LiuYung-Hsiang Chen
Dec 31, 2011·Stem Cell Research & Therapy·Rubens Camargo Siqueira
Jun 10, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuan-yuan ShiNico van Rooijen
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Małgorzata NitaUrszula Mazurek
Jun 14, 2016·Stem Cells International·Padma Priya SivanSuresh Kumar
Mar 19, 2016·Molecular Reproduction and Development·Fan GaoHuiyuan Hou
Feb 27, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J HeesterbeekAnneke I den Hollander
Oct 21, 2010·Current Eye Research·Aaron W Joe, Kevin Gregory-Evans
Oct 9, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianqian ZhengShuai Shi
Aug 10, 2017·International Journal of Molecular Sciences·Suet Lee Shirley DingPooi Ling Mok
Jan 8, 2021·Stem Cell Reviews and Reports·Sanjucta AdakBithiah Grace Jaganathan
May 20, 2020·The Journal of Comparative Neurology·Yolanda de Diego-OteroLucía Pérez Costillas

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