A Therapeutic Strategy for Resectable Pancreatic Cancer Based on Risk Factors of Early Recurrence

Pancreas
Hiroshi KuraharaShoji Natsugoe

Abstract

The aim of this study was to identify risk factors for early recurrence and assess the prognostic benefit of neoadjuvant therapy (NAT) for resectable pancreatic cancer. Patients with radiographically resectable pancreatic cancer according to the National Comprehensive Cancer Network guidelines were enrolled. We regarded recurrence within 6 months after surgery as early recurrence. This study involved 115 patients (80 who underwent upfront surgery and 35 who received NAT). Serum carbohydrate antigen 19-9 greater than 85 U/mL and p53 expression in 0 or more than 80% of tumor cells were independent risk factors for early recurrence after upfront surgery. We classified patients into a high-risk group (1 or 2 risk factors) and a low-risk group (no risk factors). In the high-risk group, the median overall survival time of patients with NAT was significantly longer than that of patients without NAT (P = 0.028). By contrast, the median overall survival time was not different according to NAT in the low-risk group. Serum carbohydrate antigen 19-9 and p53 expression of the primary tumor could be predictors of early recurrence in patients with resectable pancreatic cancer. The prognosis of patients with a high risk of early recurrence may...Continue Reading

References

Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·A ObataE Yumoto
Mar 21, 2002·Nature Reviews. Cancer·T Soussi, C Béroud
Mar 6, 2009·Archives of Pathology & Laboratory Medicine·Shinichi Yachida, Christine A Iacobuzio-Donahue
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haeryoung KimMichael Goggins
Aug 8, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoDeborah A Freedman-Cass
Jan 20, 2015·Annals of Surgery·Douglas B EvansBeth A Erickson
Jun 11, 2015·JAMA Surgery·Alessandro PanicciaCsaba Gajdos
Feb 3, 2016·Lancet·Terumi KamisawaKyoichi Takaori
Mar 5, 2016·World Journal of Surgery·Hiroshi KuraharaShoji Natsugoe
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ali A MokdadPatricio M Polanco

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Citations

Feb 4, 2021·Annals of Gastroenterological Surgery·Keinosuke IshidoTaiichi Wakiya
May 19, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jia-Chen GeDian-Rong Xiu
Jul 10, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hadi M H DiabLars N Jørgensen
Feb 20, 2021·Annals of Surgical Oncology·Hiroshi KuraharaTakao Ohtsuka

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