A therapeutic trial of cefotaxime versus penicillin-gentamicin for severe infections in children

The Journal of Antimicrobial Chemotherapy
I E Haffejee

Abstract

A single-blind therapeutic trial, using randomly either cefotaxime or a benzyl-penicillin-gentamicin combination, was carried out in 68 hospitalised paediatric patients with 72 episodes of severe infection, which were, in the main, septicaemia, pneumonia, neonatal meningitis and a few other miscellaneous infections. The cefotaxime group showed a cure rate of 94.4% compared with 72.2% in the other group. One patient with bacterial meningitis treated initially with cefotaxime died a month later; however, penicillin and chloramphenicol had been added due to clinical deterioration. In the penicillin-gentamicin group there were five deaths, all from suspected neonatal septicaemia, and three cases required a change in antibiotic regimen before a cure could be effected. The results indicate that cefotaxime should be considered a drug of choice in many neonates with life-threatening sepsis.

Citations

Aug 2, 2013·The Journal of Antimicrobial Chemotherapy·Clarissa OeserMike Sharland
Feb 19, 2014·Current Infectious Disease Reports·James W GrayPhilip Milner
Sep 26, 2013·Journal of Tropical Pediatrics·Suresh RamasamyBetsy Mathai
Aug 1, 1986·Journal of Clinical and Hospital Pharmacy·A C Lafong, P G Murphy
Jul 22, 2005·The Cochrane Database of Systematic Reviews·A Gordon, H E Jeffery
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May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen
May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen

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