A thermodynamic and theoretical view for enzyme regulation

Biochemistry. Biokhimii︠a︡
Qinyi Zhao

Abstract

Precise regulation is fundamental to the proper functioning of enzymes in a cell. Current opinions about this, such as allosteric regulation and dynamic contribution to enzyme regulation, are experimental models and substantially empirical. Here we proposed a theoretical and thermodynamic model of enzyme regulation. The main idea is that enzyme regulation is processed via the regulation of abundance of active conformation in the reaction buffer. The theoretical foundation, experimental evidence, and experimental criteria to test our model are discussed and reviewed. We conclude that basic principles of enzyme regulation are laws of protein thermodynamics and it can be analyzed using the concept of distribution curve of active conformations of enzymes.

References

Mar 6, 1992·Science·L HedstromW J Rutter
Feb 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R T Ogata, H M McConnell
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J A HewittM F Perutz
Jan 1, 1984·European Biophysics Journal : EBJ·A Cooper, D T Dryden
Jan 1, 1994·Critical Reviews in Biochemistry and Molecular Biology·T W Traut
Aug 10, 1993·Biochemistry·L M Mayr, F X Schmid
Nov 1, 1995·Protein Science : a Publication of the Protein Society·C N PaceT Gray
Oct 1, 1996·Biophysical Journal·R L Baldwin
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·P ZávodszkyG A Petsko
Oct 6, 1998·Annual Review of Biochemistry·V L Schramm
Oct 18, 2001·Protein Science : a Publication of the Protein Society·S BrunoA Mozzarelli
Aug 22, 2002·The Journal of Biological Chemistry·Daniel E Koshland, Kambiz Hamadani
Nov 6, 2002·Biochemistry·Abani K Bhuyan
Dec 12, 2002·Chemical Reviews·Lizbeth Hedstrom
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Dec 5, 2003·European Journal of Biochemistry·Gabriel ZoldákErik Sedlák
Feb 8, 2006·Annual Review of Physiology·I Scott RamseyDavid E Clapham
Mar 21, 2008·Journal of Molecular Biology·Chung-Jung TsaiRuth Nussinov
Jul 22, 2008·Nature Chemical Biology·Nina M Goodey, Stephen J Benkovic
May 28, 2009·IUBMB Life·Qinyi Zhao
Mar 20, 2010·Annual Review of Biochemistry·Olga Khersonsky, Dan S Tawfik
Oct 26, 2010·Trends in Biochemical Sciences·Susan S Taylor, Alexandr P Kornev
Nov 9, 2010·Protein and Peptide Letters·Qinyi Zhao
Nov 27, 2010·Current Opinion in Structural Biology·Shiou-Ru Tzeng, Charalampos G Kalodimos
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zachary D NagelJudith P Klinman
Mar 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hesam N Motlagh, Vincent J Hilser
Jul 3, 2013·FEBS Letters·Roy M Daniel, Michael J Danson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BMJ : British Medical Journal
K Barraclough
Advances in Enzymology and Related Areas of Molecular Biology
E R Stadtman
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
E Kvamme
Ceskoslovenská fysiologie
L Fruhaufová
© 2022 Meta ULC. All rights reserved