A thermodynamically motivated model for stress-fiber reorganization

Biomechanics and Modeling in Mechanobiology
A VigliottiV S Deshpande

Abstract

We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These kinetics are motivated by considering the enthalpies of the actin/myosin functional units that constitute the stress fibers. The stress, strain and strain rate dependence of the stress-fiber dynamics are natural outcomes of the approach. The model is presented in a general 3D framework and includes the transport of the unbound stress-fiber proteins. Predictions of the model for a range of cyclic loadings are illustrated to rationalize hitherto apparently contrasting observations. These observations include: (1) For strain amplitudes around 10 % and cyclic frequencies of about 1 Hz, stress fibers align perpendicular to the straining direction in cells subjected to cyclic straining on a 2D substrate while the stress fibers align parallel with the straining direction in cells constrained in a 3D tissue. (2) At lower applied cyclic frequencies, stress fibers in cells on 2D substrates display no sensitivity to symmetric applied strain versus time waveforms but realign in response to applied loadings with a fast lengthen...Continue Reading

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Citations

Jun 25, 2017·Journal of Cell Science·Yekaterina A MiroshnikovaSara A Wickström
Jul 11, 2018·Biomechanics and Modeling in Mechanobiology·S S ShishvanV S Deshpande
Jan 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kellen ChenJeffrey W Holmes
Jan 21, 2018·Scientific Reports·Pim J A OomenSandra Loerakker
Mar 29, 2019·Biomechanics and Modeling in Mechanobiology·Noy CohenRobert M McMeeking
Dec 19, 2019·Journal of the Royal Society, Interface·H SureshV S Deshpande
Aug 11, 2020·Biomechanics and Modeling in Mechanobiology·Takumi SaitoShinji Deguchi
Aug 20, 2019·Computer Methods in Biomechanics and Biomedical Engineering·M A J van KelleS Loerakker
Jan 31, 2017·Biomechanics and Modeling in Mechanobiology·Horacio López-Menéndez, José Félix Rodríguez
Jul 16, 2017·Scientific Reports·Alessio GizziAlberto Rainer
Feb 21, 2019·Biomechanics and Modeling in Mechanobiology·Eoin McEvoyPatrick McGarry
Jul 24, 2020·Progress in Biophysics and Molecular Biology·Kyoko Yoshida, Jeffrey W Holmes

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