A thermosensitive vaginal gel formulation with HPgammaCD for the pH-dependent release and solubilization of amphotericin B

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Ye-Tae KimJeong-Sook Park

Abstract

To achieve better therapeutic efficacy and patient compliance in the treatment for Candida vaginitis, the antifungal agent amphotericin B (AmB) was formulated in a vaginal gel using Pluronic-based multiblock copolymers (MBCP-2). To increase its aqueous solubility, the drug was incorporated as its inclusion complex with hydroxypropyl-gamma-cyclodextrin (HPgammaCD). The formation of the AmB inclusion complex was characterized using different techniques including XRD, FT-IR spectrophotometry, DSC, and SEM. The sol-gel transition diagrams were determined by the inversion method at temperature intervals of 2 degrees C. Moreover, a histopathology study was performed to determine whether vaginal tissue damage was caused by repeated doses. The inclusion complex between AmB and HPgammaCD was completely formed, and the aqueous solubility of AmB was improved by the formation of the inclusion complex. The sol-gel transition diagrams showed that the aqueous solutions of MBCP-2 gelled at body temperature, and the gelation temperature of the polymer solutions was dependent on polymer concentration. In vitro drug release results indicated that MBCP-2 exhibited a sustained release of AmB in pH 7.4 and pH 9.0 buffers, whereas at pH 5.0, it prese...Continue Reading

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Citations

May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Željka Vanić, Nataša Škalko-Basnet
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Rahamatullah ShaikhRyan F Donnelly
Mar 14, 2012·Drug Development and Industrial Pharmacy·Baek-Ki ShinJeong-Sook Park
Sep 1, 2015·International Journal of Pharmaceutics·Claudia Luengo-AlonsoPaolo Caliceti
May 20, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chaocheng LuLi Luo
Nov 26, 2010·International Journal of Pharmaceutics·Seo-Ryung KimChong-Kook Kim
Jan 24, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ashley Cox ParkerWarren O Haggard
Oct 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianping ChenJianyu Su
Nov 4, 2017·Journal of Drug Targeting·Sebastien TaurinMargit M Janát-Amsbury
Nov 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley Cox ParkerWarren O Haggard
Jul 21, 2011·Journal of Biomaterials Science. Polymer Edition·Vivek Kumar GarripelliSeongbong Jo
Oct 18, 2019·Future Medicinal Chemistry·Hongmei XuZhimei Song
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Tingting ZhangHualin Fu
Jan 27, 2020·International Journal of Biological Macromolecules·Valéria Maria de Oliveira CardosoBeatriz Stringhetti Ferreira Cury
Sep 11, 2019·International Journal of Pharmaceutics·Rania HamedRana Abu-Huwaij
Jul 3, 2021·Pharmaceutics·Tomasz OsmałekBozena Michniak-Kohn

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