Abstract
To achieve better therapeutic efficacy and patient compliance in the treatment for Candida vaginitis, the antifungal agent amphotericin B (AmB) was formulated in a vaginal gel using Pluronic-based multiblock copolymers (MBCP-2). To increase its aqueous solubility, the drug was incorporated as its inclusion complex with hydroxypropyl-gamma-cyclodextrin (HPgammaCD). The formation of the AmB inclusion complex was characterized using different techniques including XRD, FT-IR spectrophotometry, DSC, and SEM. The sol-gel transition diagrams were determined by the inversion method at temperature intervals of 2 degrees C. Moreover, a histopathology study was performed to determine whether vaginal tissue damage was caused by repeated doses. The inclusion complex between AmB and HPgammaCD was completely formed, and the aqueous solubility of AmB was improved by the formation of the inclusion complex. The sol-gel transition diagrams showed that the aqueous solutions of MBCP-2 gelled at body temperature, and the gelation temperature of the polymer solutions was dependent on polymer concentration. In vitro drug release results indicated that MBCP-2 exhibited a sustained release of AmB in pH 7.4 and pH 9.0 buffers, whereas at pH 5.0, it prese...Continue Reading
References
Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Jul 2, 1998·Journal of Pharmaceutical Sciences·M D VeigaF Ahsan
Dec 29, 1998·Contraception·E HardyL J Zaneveld
Jan 7, 1999·Drug Development and Industrial Pharmacy·M D DhanarajuM S Moorthy
Aug 29, 2000·Infection·A Juster-ReicherA Barzilai
Feb 19, 2002·Chemical Reviews·Allan R. Hedges
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung Yun ChangChong-Kook Kim
Aug 16, 2005·International Journal of Pharmaceutics·Thorsteinn LoftssonMár Másson
Jan 13, 2006·International Journal of Pharmaceutics·G VandermeulenV Préat
Nov 14, 2006·Macromolecular Bioscience·Seongbong JoSung Wan Kim
Feb 5, 2008·International Journal of Pharmaceutics·Ki-Choon ChoiChae-Eun Song
Mar 12, 2009·Drugs·Marit D MoenLesley J Scott
Jun 16, 2009·International Journal of Pharmaceutics·Phatsawee Jansook, Thorsteinn Loftsson
Jul 15, 2009·Acta Biomaterialia·V K GarripelliS Jo
Oct 21, 2009·Journal of Microencapsulation·Pawan K AngraMartin J D'Souza
Citations
Oct 7, 2011·Pharmaceutical Research·Romina J GlisoniAlejandro Sosnik
May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Željka Vanić, Nataša Škalko-Basnet
Jun 9, 2012·International Journal of Nanomedicine·Daquan ChenWanhui Liu
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Rahamatullah ShaikhRyan F Donnelly
Mar 14, 2012·Drug Development and Industrial Pharmacy·Baek-Ki ShinJeong-Sook Park
Sep 1, 2015·International Journal of Pharmaceutics·Claudia Luengo-AlonsoPaolo Caliceti
Jul 8, 2014·International Journal of Pharmaceutics·Helga K RuizGloria Molero
May 20, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chaocheng LuLi Luo
Nov 26, 2010·International Journal of Pharmaceutics·Seo-Ryung KimChong-Kook Kim
Oct 3, 2014·PloS One·Soon Gil ChoiJeong-Sook Park
Jan 24, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ashley Cox ParkerWarren O Haggard
Oct 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianping ChenJianyu Su
Nov 4, 2017·Journal of Drug Targeting·Sebastien TaurinMargit M Janát-Amsbury
Jan 31, 2018·Journal of Drug Targeting·Tianyuan CiXue Ke
Nov 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley Cox ParkerWarren O Haggard
Oct 19, 2019·Pharmaceutics·Barbara ViganiFranca Ferrari
Jul 21, 2011·Journal of Biomaterials Science. Polymer Edition·Vivek Kumar GarripelliSeongbong Jo
Oct 18, 2019·Future Medicinal Chemistry·Hongmei XuZhimei Song
Jan 12, 2019·Drug Development and Industrial Pharmacy·Phatsawee JansookGarnpimol C Ritthidej
Oct 29, 2020·Drug Delivery·Rofida AlbashAhmed Adel Alaa-Eldin
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Tingting ZhangHualin Fu
Jan 27, 2020·International Journal of Biological Macromolecules·Valéria Maria de Oliveira CardosoBeatriz Stringhetti Ferreira Cury
Sep 11, 2019·International Journal of Pharmaceutics·Rania HamedRana Abu-Huwaij
Dec 31, 2020·Polymers·Manisha PandeyLim Win Yi
Jun 3, 2021·Pharmaceutics·Aleph M S SouzaEryvaldo S T Egito
Jul 3, 2021·Pharmaceutics·Tomasz OsmałekBozena Michniak-Kohn