A thesaurus for a neural population code

ELife
Elad GanmorElad Schneidman

Abstract

Information is carried in the brain by the joint spiking patterns of large groups of noisy, unreliable neurons. This noise limits the capacity of the neural code and determines how information can be transmitted and read-out. To accurately decode, the brain must overcome this noise and identify which patterns are semantically similar. We use models of network encoding noise to learn a thesaurus for populations of neurons in the vertebrate retina responding to artificial and natural videos, measuring the similarity between population responses to visual stimuli based on the information they carry. This thesaurus reveals that the code is organized in clusters of synonymous activity patterns that are similar in meaning but may differ considerably in their structure. This organization is highly reminiscent of the design of engineered codes. We suggest that the brain may use this structure and show how it allows accurate decoding of novel stimuli from novel spiking patterns.

References

Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Jun 9, 1995·Science·Z F Mainen, T J Sejnowski
Jan 1, 1994·Journal of Neuroscience Methods·M MeisterD A Baylor
Mar 21, 1997·Science·R R de Ruyter van SteveninckW Bialek
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·M J BerryM Meister
Nov 14, 1997·Journal of Neurophysiology·D K WarlandM Meister
Feb 24, 1998·Neural Computation·R S ZemelA Pouget
Feb 9, 1999·Neural Computation·L F Abbott, P Dayan
Oct 20, 1999·Nature Neuroscience·A Borst, F E Theunissen
Dec 23, 2000·Science·J B TenenbaumJ C Langford
Mar 20, 2001·Neural Computation·M C van Rossum
Jun 8, 2001·Nature·S NirenbergP E Latham
Dec 12, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·H SompolinskyM Shamir
Feb 20, 2003·Neural Computation·Shun-Ichi AmariYutaka Sakai
Mar 5, 2003·Network : Computation in Neural Systems·G PolaS Panzeri
Dec 20, 2003·Physical Review Letters·Elad SchneidmanWilliam Bialek
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam Kohn, Matthew A Smith
May 11, 2005·Neuron·Jason L PuchallaMichael J Berry
May 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter E Latham, Sheila Nirenberg
Sep 6, 2005·Current Opinion in Neurobiology·Jonathan D Victor
Sep 16, 2005·Nature·Leslie C OsborneWilliam Bialek
Mar 21, 2006·Nature Neuroscience·Alan A Stocker, Eero P Simoncelli
Jun 9, 2006·Nature Reviews. Neuroscience·Bruno B AverbeckAlexandre Pouget
Aug 19, 2007·Nature·Jaime de la RochaAlex Reyes
Jan 16, 2008·Neural Computation·Conor Houghton, Kamal Sen
Mar 6, 2008·Nature Reviews. Neuroscience·A Aldo FaisalDaniel M Wolpert
Jun 3, 2008·Nature Neuroscience·Shigeyoshi FujisawaGyörgy Buzsáki
Nov 5, 2008·Frontiers in Neuroscience·Alex LoebelMisha Tsodyks
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathon ShlensE J Chichilnisky
Dec 8, 2009·Nature Neuroscience·Wilson TruccoloJohn P Donoghue
Jan 30, 2010·Science·Alexander S EckerAndreas S Tolias
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masafumi OizumiMasato Okada
Jul 6, 2010·Nature·Ifije E OhiorhenuanJonathan D Victor
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos E Vargas-IrwinJohn P Donoghue
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elad GanmorElad Schneidman
May 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elad GanmorElad Schneidman
Sep 13, 2011·Progress in Neurobiology·Edmund T Rolls, Alessandro Treves
Sep 13, 2011·Nature Neuroscience·Sameet Sreenivasan, Ila Fiete

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Citations

Feb 26, 2016·Nature Neuroscience·Brent DoironKrešimir Josić
Mar 27, 2016·Current Opinion in Neurobiology·Elad Schneidman
Nov 5, 2016·PLoS Computational Biology·Arno OnkenStefano Panzeri
Jun 9, 2017·Neuron·Juan A GallegoSara A Solla
Dec 24, 2018·Neural Computation·Christophe GardellaThierry Mora
Dec 10, 2019·PLoS Computational Biology·Richard F BetzelDanielle S Bassett
Oct 12, 2017·PLoS Computational Biology·Mark L Ioffe, Michael J Berry
Nov 27, 2019·Nature Neuroscience·Dana Rubi LevyOfer Yizhar
Jul 15, 2016·Physical Review. E·Haiping Huang, Taro Toyoizumi
Apr 2, 2020·Frontiers in Computational Neuroscience·Michael J Berry, Gašper Tkačik
Apr 14, 2018·Biological cybernetics·Pietro QuaglioSonja Grün
Oct 23, 2020·Journal of Neural Engineering·Nishal P Shah, E J Chichilnisky
Oct 6, 2021·ELife·Sacha SokoloskiRuben Coen-Cagli

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Software Mentioned

MATLAB
Isomap

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