PMID: 8939428Nov 1, 1996Paper

A third family of allelic hsd genes in Salmonella enterica: sequence comparisons with related proteins identify conserved regions implicated in restriction of DNA

Molecular Microbiology
A J TitheradgeN E Murray

Abstract

Salmonella enterica serovar blegdam has a restriction and modification system encoded by genes linked to serB. We have cloned these genes, putative alleles of the hsd locus of Escherichia coli K-12, and confirmed by the sequence similarities of flanking DNA that the hsd genes of S. enterica serovar blegdam have the same chromosomal location as those of E. coli K-12 and Salmonella enterica serovar typhimurium LT2. There is, however, no obvious similarity in their nucleotide sequences, and while the gene order in S. enterica serovar blegdam is serB hsdM, S and R, that in E. coli K-12 and S. enterica serovar typhimurium LT2 is serB hsdR, M and S. The hsd genes of S. enterica serovar blegdam identify a third family of serB-linked hsd genes (type ID). The polypeptide sequence predicted from the three hsd genes show some similarities (18-50% identity) with the polypeptides of known and putative type I restriction and modification systems; the highest levels of identity are with sequences of Haemophilus influenzae Rd. The HsdM polypeptide has the motifs characteristic of adenine methyltransferases. Comparisons of the HsdR sequence with those for three other families of type I systems and three putative HsdR polypeptides identify two h...Continue Reading

Citations

Feb 9, 2010·Nature Reviews. Microbiology·Yogitha N SrikhantaMichael P Jennings
Sep 15, 2001·Nucleic Acids Research·D T DrydenD N Rao
Dec 5, 2003·Nucleic Acids Research·Wil A M Loenen
Jan 28, 2004·Nucleic Acids Research·Marion H Sibley, Elisabeth A Raleigh
May 31, 2008·Nucleic Acids Research·Eva SisákováMark D Szczelkun
Sep 30, 2008·Applied and Environmental Microbiology·Hyuk-Joon KwonSun-Joong Kim
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·N E Murray
Sep 8, 2004·Journal of Nanobiotechnology·Sivanand S PennadamDariusz C Górecki
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MakovetsN E Murray
Jan 24, 2002·Molecular Cell·M D WalkinshawD T F Dryden
Jan 1, 2008·Journal of Molecular Biology·Agnieszka Obarska-KosinskaG Geoff Kneale
Jul 3, 1999·Journal of Molecular Biology·G P DaviesD T Dryden
Oct 20, 1999·Journal of Molecular Biology·G P DaviesN E Murray
Feb 5, 2000·Journal of Molecular Biology·P Janscak, T A Bickle
Aug 22, 1997·Journal of Molecular Biology·N S LeeJ Ryu

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