A three-dimensional computer model of four hypothetical mechanisms protecting biofilms from antimicrobials

Applied and Environmental Microbiology
Jason D ChamblessPhilip S Stewart

Abstract

Four hypothetical mechanisms for protection of biofilms against antimicrobials were incorporated into a three-dimensional model of biofilm growth and development. The model integrated processes of substrate utilization, diffusion, growth, cell migration, death, and detachment in a cellular automaton framework. Compared to simulations of unprotected biofilms, each of the protective mechanisms provided some tolerance to antimicrobial action. When the mechanisms were compared to each other, the behaviors of the four protective mechanisms produced distinct shapes of killing curves, nonuniform spatial patterns of survival and cell type distribution, and anticipated susceptibility patterns for dispersed biofilm cells. The differences between the protective mechanisms predicted in these simulations could guide the design of experiments to discriminate antimicrobial tolerance mechanisms in biofilms. Each of the mechanisms could be a plausible avenue of biofilm protection.

References

Dec 1, 1992·The Journal of Antimicrobial Chemotherapy·I G DuguidP Gilbert
Oct 1, 1990·The Journal of Antimicrobial Chemotherapy·D J EvansP Gilbert
May 1, 1989·Journal of General Microbiology·W W NicholsH L Walmsley
Dec 1, 1988·The Journal of Antimicrobial Chemotherapy·M R BrownP Gilbert
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·P A SuciG G Geesey
Sep 1, 1994·The Journal of Infectious Diseases·R O DarouicheD M Musher
Dec 1, 1993·Antimicrobial Agents and Chemotherapy·W M DunneS L Kaplan
May 1, 1996·Biotechnology Progress·E J WentlandG A McFeters
Nov 1, 1996·Antimicrobial Agents and Chemotherapy·P S Stewart
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·G S Baillie, L J Douglas
Oct 6, 1998·Applied and Environmental Microbiology·K D XuG A McFeters
Jan 12, 1999·Microbiology·Jan-Ulrich KreftJulian W T Wimpenny
Sep 3, 1999·Applied and Environmental Microbiology·C SternbergS Molin
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·A BroounK Lewis
Mar 29, 2000·Journal of Applied Microbiology·W L CochranP S Stewart
Apr 4, 2000·Biotechnology and Bioengineering·M G DoddsP S Stewart
Feb 13, 2001·Trends in Microbiology·T F Mah, G A O'Toole
Mar 21, 2001·Antimicrobial Agents and Chemotherapy·K Lewis
Jul 21, 2001·Lancet·P S Stewart, J W Costerton
Sep 15, 2001·Journal of Applied Microbiology·P S StewartW M Rees
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Zhilan Zheng, Philip S Stewart
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Philip S Stewart
Feb 4, 2003·Nature Reviews. Drug Discovery·David Davies
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Mark E Roberts, Philip S Stewart
May 17, 2005·Bulletin of Mathematical Biology·N G CoganLisa Fauci
Jul 14, 2005·Environmental Microbiology·Barbara SzomolayPhil S Stewart
May 1, 1994·Biotechnology and Bioengineering·D de BeerZ Lewandowski
Feb 20, 1996·Biotechnology and Bioengineering·P S StewartB T Schneider

❮ Previous
Next ❯

Citations

Sep 26, 2006·Odontology·Jacob M ten Cate
Feb 10, 2012·Bulletin of Mathematical Biology·Tianyu Zhang
Jun 27, 2013·The Journal of Antibiotics·Joanna Kwiecińska-PirógEugenia Gospodarek
Jun 21, 2013·Biofouling·Hans-Curt FlemmingTobias Schild
May 25, 2010·DNA and Cell Biology·Victor V Tetz, George V Tetz
Sep 22, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Maria SaltaKeith R Stokes
Aug 11, 2010·Antimicrobial Agents and Chemotherapy·Marie Tré-HardyJean-Paul Dehaye
Dec 10, 2008·Antimicrobial Agents and Chemotherapy·George V TetzVictor V Tetz
Jan 27, 2009·Applied and Environmental Microbiology·Claire PerrinCorinne Dorel
Nov 10, 2012·Journal of Applied Oral Science : Revista FOB·Fabíola Galbiatti de CarvalhoFranklin Garcia-Godoy
Oct 30, 2010·Paediatric Drugs·Mireille van Westreenen, Harm A W M Tiddens
Nov 17, 2011·Drugs·Spyridon PagkalisMatthew E Falagas
Jul 1, 2014·PloS One·Nil TandoganEdgar D Goluch
Apr 23, 2014·Biomicrofluidics·Pegah N AbadianEdgar D Goluch
Dec 17, 2008·Journal of Mathematical Biology·Patrick De Leenheer, N G Cogan
Apr 15, 2014·Journal of Molecular Biology·Vanni Bucci, Joao B Xavier
Apr 12, 2011·Theoretical Biology & Medical Modelling·Mallory R FrederickHermann J Eberl
Feb 5, 2016·Aesthetic Surgery Journal·Dragana AjdicSeth Thaller
May 1, 2013·Mathematical Biosciences·A E StineA Milsted
Jun 13, 2008·Journal of Theoretical Biology·Hermann J Eberl, Rangarajan Sudarsan
Apr 6, 2007·Journal of Microbiological Methods·Sara K FilocheChris H Sissons
Feb 5, 2009·Biotechnology and Bioengineering·Jennifer A HornemannJoseph D Seymour
Dec 15, 2010·Biotechnology Journal·Friederike BuchholzThomas Maskow
Feb 13, 2014·Microscopy Research and Technique·Paula Regina De SouzaEvandro Watanabe
Nov 20, 2015·Bulletin of Mathematical Biology·Kazi A RahmanHermann J Eberl
Nov 19, 2014·Environmental Microbiology·Barbara Szomolay, N G Cogan
Jun 7, 2015·International Journal of Biological Macromolecules·Małgorzata PleszczyńskaJanusz Szczodrak
May 23, 2012·Acta Odontologica Scandinavica·Ronald Ordinola-ZapataMarco A H Duarte
Jun 16, 2015·Frontiers in Microbiology·Kotaro ChiharaSatoshi Tsuneda
May 9, 2014·Biophysical Journal·Tomas StorckDamien J Batstone
Aug 31, 2007·FEMS Immunology and Medical Microbiology·Victoria KostenkoRobert John Martinuzzi
May 21, 2016·Frontiers in Microbiology·Sylvie MiquelChristiane Forestier
Jun 11, 2016·International Wound Journal·Silvestre Ortega-PeñaEdgar Krötzsch
Jul 22, 2015·PloS One·Blessing O EmereniniHermann J Eberl
Aug 8, 2009·Advances in Dental Research·J M Bob ten Cate
Apr 25, 2018·Bulletin of Mathematical Biology·Maryam GhasemiChristina Kuttler
Apr 18, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jake A MooneyDerek F Amanatullah
May 12, 2018·Critical Reviews in Microbiology·Fabian CieplikTim Maisch
Nov 26, 2015·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Szymon Skoneczny
Oct 16, 2015·Antimicrobial Agents and Chemotherapy·Thet Tun AungRoger W Beuerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.