A three-dimensional study of endometrial microvessels in women using the contraceptive subdermal levonorgestrel implant system, norplant

Micron : the International Research and Review Journal for Microscopy
M SimbarI Fraser

Abstract

Recent evidence points towards a substantial disturbance of the process of angiogenesis within the endometrium in women who are exposed continuously to low dose contraceptive progestogens. This results in the patchy appearance of abnormally small and abnormally large, thin-walled vessels in the superficial regions of exposed endometrium. Three-dimensional pictures were developed from digitised images of serial tissue sections of endometrium in which microvascular endothelial cells were labelled with antibodies to the endothelial cell surface antigen, CD34 and their basement membranes labelled with anti-Collagen IV antibodies. Microvessels from endometrium exposed to continuous low-dose levonorgestrel from a subdermal implant system (Norplant) displayed considerable variations in size and shape. No spiral arterioles were identified. Some microvessels showed considerable dilatation, distortion and variability in the presence of surrounding basement membrane components. Other endothelial structures included narrow, solid cords of endothelial cells, without basement membranes, which often connected with normal or abnormal vessels containing lumens. Some areas, especially deeper in the tissue, contained microvessels of normal size a...Continue Reading

References

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Mar 1, 1981·Microvascular Research·P M Blackwell, I S Fraser
Apr 30, 1999·Human Reproduction·M HickeyI S Fraser
Feb 28, 2002·Human Reproduction Update·Mark Livingstone, Ian S Fraser
Dec 19, 2003·Micron : the International Research and Review Journal for Microscopy·F ManconiI S Fraser

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Citations

Oct 8, 2005·Angiogenesis·Oliver P Milling Smith, Hilary O D Critchley
Oct 8, 2005·Angiogenesis·Jane E Girling, Peter A W Rogers
Dec 19, 2003·Micron : the International Research and Review Journal for Microscopy·F ManconiI S Fraser
Dec 5, 2013·Nano Letters·Joseph M GroganHaim H Bau
Jan 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olga B IoffeGeorge L Mutter
Feb 1, 2006·Reproductive Biology and Endocrinology : RB&E·Frederick SchatzCharles J Lockwood
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Kristof ChwaliszWalter Elger
Nov 17, 2009·Microvascular Research·Frank ManconiIan S Fraser
Oct 11, 2007·The Journal of Family Planning and Reproductive Health Care·Masoumeh SimbarIan S Fraser
Feb 22, 2008·Archives of Sexual Behavior·Mary A OttJ Dennis Fortenberry
Sep 17, 2011·Journal of General Internal Medicine·Eleanor Bimla SchwarzMichael A Horberg
Sep 10, 2020·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Aug 28, 2021·Journal of Personalized Medicine·Manako YamaguchiTakayuki Enomoto

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