A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Aysun Kiliç, M Turan Akay

Abstract

For the last ten years, in accordance with the increased use of genetically modified (GM) foods for human and livestock, a large number of feeding studies have been carried out. However, the evidence is still far from proving whether the long-term consumption of GM foods poses a possible danger for human or animal health. Therefore, this study was designed to evaluate the effects of transgenic corn on the rats that were fed through three generations with either GM corn or its conventional counterpart. Tissue samples of stomach, duodenum, liver and kidney were obtained for histopathological examinations. The average diameter of glomeruli, thickness of renal cortex and glomerular volume were calculated and number of affected animals/number of examined animals for liver and kidney histopathology were determined. Amounts of urea, urea nitrogen, creatinine, uric acid, total protein, albumin and globulin were determined; enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase, creatine kinase and amylase were measured in serum samples. No statistically significant differences were found in relative organ weights of rats within groups but there were some minimal histop...Continue Reading

References

Feb 1, 1990·Journal of Electron Microscopy Technique·D L Schmucker
Feb 26, 1999·BMJ : British Medical Journal·L Jones
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Denise G Brake, Donald P Evenson
Jan 20, 2004·Nature Biotechnology·Trudy NetherwoodHarry J Gilbert
Apr 28, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B HammondM Nemeth
Oct 26, 2005·Transgenic Research·Raffaele MazzaAdriano Marocco
Feb 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G HammondM A Nemeth
Oct 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Malene SchrøderIb Knudsen
Oct 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Morten PoulsenIb Knudsen
Nov 14, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Susan A MacKenzieBryan Delaney

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Citations

Jul 8, 2011·The British Journal of Nutrition·Maria C WalshPeadar G Lawlor
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·W Zhang, F Shi
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·S G BuzoianuP G Lawlor
Sep 12, 2013·Nature Biotechnology·Laura DeFrancesco
Sep 27, 2013·Journal of Animal Science and Biotechnology·Alison L Van Eenennaam
Aug 2, 2014·PloS One·Daniela ReinerMichelle M Epstein
Sep 24, 2010·Journal of Biomedicine & Biotechnology·Luciane Mourão GuimarãesMaria Fátima Grossi-de-Sa
Dec 4, 2015·International Journal of Environmental Research and Public Health·Qian-ying GuoYong Li
May 14, 2011·Journal of Integrative Plant Biology·Hui-Lin YuKong-Ming Wu
Apr 27, 2011·Journal of the Science of Food and Agriculture·Yanfang YuanKunlun Huang
Nov 6, 2015·Journal of Applied Toxicology : JAT·Néstor Rubio-Infante, Leticia Moreno-Fierros
Oct 30, 2013·Critical Reviews in Toxicology·Andrew BartholomaeusUNKNOWN ILSI International Food Biotechnology Committee Task Force on Use of Mammalian Toxicology Studies in Safety Assessment of GM
Dec 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Er Hui WangHai Bin Xu
Apr 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xing Hua ZhouQiao Quan Liu
Mar 23, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ana Janaina J M LemosJosé V Oliveira
Sep 10, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xing Hua ZhouQiao Quan Liu
Dec 14, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chelsea SnellAgnès E Ricroch
Sep 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Er Hui WangHai Bin Xu
Nov 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min ZhangXiaoguang Yang
Feb 27, 2016·Animal : an International Journal of Animal Bioscience·R Q ZhongH F Zhang
Jan 19, 2016·Journal of the Science of Food and Agriculture·Liang ChenHongfu Zhang
Sep 4, 2014·Journal of Animal Science·A L Van Eenennaam, A E Young
Apr 21, 2017·Asian-Australasian Journal of Animal Sciences·Xiang XuFa-Zhi Xu
Jul 6, 2019·Current Medicinal Chemistry·Bogdan Bumbăcilă, Mihai V Putz
Jul 16, 2017·Plant Biotechnology Journal·Miguel A Sánchez, Wayne A Parrott
Sep 21, 2017·Journal of Food Science and Technology·Deepa TeradalRavindranath H Aladakatti
Apr 28, 2017·Frontiers in Public Health·Michael N Antoniou, Claire J Robinson
Jul 11, 2020·Journal of Agricultural and Food Chemistry·Yichun HuXiaoguang Yang

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