A three-part controlled study of trimebutine in the treatment of irritable colon syndrome

Current Medical Research and Opinion
K Lüttecke

Abstract

Three controlled trials were carried out in patients with irritable bowel syndrome to assess the effectiveness of trimebutine in controlling the symptoms of abdominal distension, pain, flatulence, constipation, diarrhoea and dyspepsia. In the first two trials, it was shown that 200 mg trimebutine 3-times daily for 3 days produced rapid relief of symptoms and was significantly (p less than 0.001) more effective than placebo, but not significantly so when the dosage level was halved. In the third trial, the results showed that 200 mg trimebutine 3-times daily for 2 weeks was as effective as 100 mg mebeverine 4-times daily in relieving the major symptoms and in improving motility. No serious side-effects were reported with trimebutine at the dosage used.

References

Jan 1, 1978·The Journal of International Medical Research·K Lüttecke
Jan 1, 1979·The Journal of International Medical Research·M G Moshal, M Herron

❮ Previous
Next ❯

Citations

Dec 15, 1987·European Journal of Pharmacology·H KotakeH Mashiba
Apr 3, 1991·European Journal of Pharmacology·M NagasakiH Tamaki
May 3, 2005·Gastroenterology Clinics of North America·Philip Schoenfeld
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·T PoynardY Benhamou
Sep 1, 1993·British Journal of Pharmacology·M NagasakiH Ohashi
May 10, 2007·Gut·R SpillerUNKNOWN Clinical Services Committee of The British Society of Gastroenterology
Feb 4, 2010·World Journal of Gastroenterology : WJG·Mahnaz Darvish-DamavandiMohammad Abdollahi
Nov 8, 2013·Journal of Neurogastroenterology and Motility·A Young SeoDong Hyun Oh
May 1, 1996·Scandinavian Journal of Gastroenterology·P S EfskindM H Vatn
Apr 15, 2011·Alimentary Pharmacology & Therapeutics·M Schmulson, L Chang
May 1, 1989·The Journal of Pharmacy and Pharmacology·O IgawaH Mashiba
Jun 8, 2012·Revista de gastroenterología de México·M A Martínez-VázquezF J Bosques-Padilla
Nov 25, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Suh-Young LeeHye-Ryun Kang
Jun 5, 2016·Gastroenterology Clinics of North America·Lucinda A HarrisMargaret M Heitkemper
Feb 26, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Joong Goo KwonUNKNOWN Korean Society of Neurogastroenterology and Motility
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·J TackG Fisher
Aug 13, 2011·The Cochrane Database of Systematic Reviews·Lisa RuepertJean Wm Muris
Oct 1, 1994·Alimentary Pharmacology & Therapeutics·T PoynardJ C Chaput
May 1, 1987·The Journal of Pharmacy and Pharmacology·F RomanJ L Junien
Nov 19, 1997·The Journal of International Medical Research·M Delvaux, D Wingate
Oct 17, 2019·Minerva gastroenterologica e dietologica·Beatrice Salvioli
Feb 5, 2021·Journal of Gastroenterology·Shin FukudoKazuhiko Koike

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.