PMID: 6974005Jul 20, 1981Paper

A three-state model for inactivation of sodium permeability

Biochimica Et Biophysica Acta
G OchsJ R Schwarz

Abstract

The inactivation of Na+ permeability in single myelinated motor nerve fibres of Rana esculenta was investigated under voltage and current clamp conditions at 20 degrees C in Ringer's solution and under blocked K+ currents. Development of inactivation and its recovery was described by two potential-dependent time constants: The smaller time constant followed the usual bell-shaped function of membrane potential, whereas the larger one was monotone-increasing with more negative potentials. Several three-state models for inactivation were investigated. The experiments could best be approximated by a model with two open and one closed state for inactivation following: open in equilibrium closed in equilibrium open. Rate constants were determined for all transitions shown from the voltage clamp experiments. The action potentials computed by means of the proposed model were in good agreement with those measured, both in Ringer's solution and under blocked K+ current conditions.

Citations

Sep 1, 1989·Pflügers Archiv : European journal of physiology·J A Pohl
Jul 1, 1983·Pflügers Archiv : European journal of physiology·J R SchwarzJ L Weytjens
May 1, 1985·Pflügers Archiv : European journal of physiology·J Schmidtmayer
Aug 1, 1987·Pflügers Archiv : European journal of physiology·J R Schwarz, G Eikhof
Apr 1, 1986·Pflügers Archiv : European journal of physiology·J R Schwarz
Jan 1, 1993·The Journal of Membrane Biology·S F LinW Z Rymer
Jun 17, 1983·European Journal of Pharmacology·J R Schwarz, R P Spielmann
Aug 1, 1997·Progress in Neurobiology·J R Elliott, M E Bräu
Nov 1, 1985·The Journal of General Physiology·G K Wang, G Strichartz
Sep 27, 2005·Physiological Reviews·Werner Ulbricht
Jun 22, 1990·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R D KeynesI C Forster
Jun 22, 1990·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R D Keynes
Mar 26, 1998·Neuroscience and Behavioral Physiology·B V KrylovI I Vilin
Jul 1, 1987·Pflügers Archiv : European journal of physiology·T Meeder, W Ulbricht

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