A thyroxine-containing thyroglobulin peptide induces both lymphocytic and granulomatous forms of experimental autoimmune thyroiditis

Journal of Autoimmunity
H Braley-Mullen, G C Sharp

Abstract

Mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg can induce two histologically distinct forms of experimental autoimmune thyroiditis (EAT). MTg-sensitized cells activated with MTg alone induce a mild chronic form of EAT in which the thyroid infiltrate consists primarily of lymphocytes and other mononuclear cells (lymphocytic EAT). The same donor cells activated with MTg and anti-IL2R mAb induce a more severe and acute form of EAT with a thyroid inflammatory lesion having granulomatous histopathological features. A thyroxine-containing (T4) peptide, corresponding to positions 2549-2560 of human Tg, was shown by others to activate spleen cells of mouse thyroglobulin (MTg)-sensitized CBA/J mice to induce lymphocytic EAT. To determine if the CD4+ effector T cells that induce granulomatous EAT can respond to the same T-cell epitope, the present study was undertaken to determine if both forms of EAT could be induced by the 2549-2560 thyroxine (T4)-containing peptide. This peptide was very effective for activation of T cells from MTg-primed CBA/J donors to induce granulomatous EAT but, in contrast to MTg, did not activate T cells from AKR/J or DBA/1 mice to induce granulomatous EAT. The T4 peptide did not ...Continue Reading

Citations

Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Pavel PichurinSandra M McLachlan
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·George Carayanniotis
Dec 29, 2000·International Reviews of Immunology·E A Stafford, N R Rose
Dec 29, 2000·International Reviews of Immunology·H Braley-Mullen, G C Sharp
Dec 13, 2003·Autoimmunity·George Carayanniotis
Jun 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Panayota KolypetriGeorge Carayanniotis
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haiyan S Li, George Carayanniotis
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang D DaiGeorge Carayanniotis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.