A tiered approach for risk-benefit assessment of foods

Risk Analysis : an Official Publication of the Society for Risk Analysis
Heidi FransenH Verhagen

Abstract

Risk-benefit analyses are introduced as a new paradigm for old problems. However, in many cases it is not always necessary to perform a full comprehensive and expensive quantitative risk-benefit assessment to solve the problem, nor is it always possible, given the lack of required date. The choice to continue from a more qualitative to a full quantitative risk-benefit assessment can be made using a tiered approach. In this article, this tiered approach for risk-benefit assessment will be addressed using a decision tree. The tiered approach described uses the same four steps as the risk assessment paradigm: hazard and benefit identification, hazard and benefit characterization, exposure assessment, and risk-benefit characterization, albeit in a different order. For the purpose of this approach, the exposure assessment has been moved upward and the dose-response modeling (part of hazard and benefit characterization) is moved to a later stage. The decision tree includes several stop moments, depending on the situation where the gathered information is sufficient to answer the initial risk-benefit question. The approach has been tested for two food ingredients. The decision tree presented in this article is useful to assist on a ca...Continue Reading

References

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Citations

Apr 11, 2012·Food & Nutrition Research·Janneke Verkaik-KloostermanHans Verhagen
Sep 18, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeljer HoekstraAndy Hart
Aug 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nynke de JongJeljer Hoekstra
Jan 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeljer HoekstraHelga Gunnlaugsdottir
Aug 6, 2011·European Journal of Pharmacology·Simone R B M EussenCathy J M Rompelberg
Jun 18, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J TijhuisH Verhagen
Oct 14, 2011·Risk Analysis : an Official Publication of the Society for Risk Analysis·Barbara Miller, Janas Sinclair
Jul 7, 2020·EFSA Journal·UNKNOWN National Food Institute, Technical University of Denmark (DTU Food), DenmarkM Nauta
Feb 6, 2019·Food Research International·Sara M PiresMaarten J Nauta
Jul 27, 2021·Frontiers in Nutrition·Sofie Theresa ThomsenRikke Andersen

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