PMID: 8945914Nov 1, 1996Paper

A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin

The American Journal of Physiology
B H PannenM G Clemens

Abstract

To test whether endothelins are involved in the regulation of portal resistance after endotoxin pretreatment and whether their effects are modulated by nitric oxide (NO), rats received intraperitoneal injections of Escherichia coli lipopolysaccharide (LPS, 1 mg/kg body wt) or saline. Six and twenty-four hours later, livers were isolated and perfused. Analyses of portal pressure-flow (P-Q) relationships and epifluorescence microscopy were performed before and after administration of 1) the NO synthesis inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 10(-3) M), followed by L-arginine (2 x 10(-3) M), or 2) the endothelin ETA/ETB-receptor antagonist bosentan (2 x 10(-4) M), followed by L-NAME (10(-3) M). LPS pretreatment increased all measures of resistance, which included total portal resistance, zero flow, incremental resistance (slopes of P-Q relationship), and sinusoid resistance. L-NAME had no effect in sham controls but increased all measures of resistance at 6 h after LPS and increased total and incremental resistance 24 h after LPS. L-Arginine reversed these changes. Bosentan reduced total and sinusoid resistance slightly in control livers and caused substantial reductions in all measures of resistance at 6 and 24 ...Continue Reading

Citations

Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B H PannenK K Geiger
Dec 20, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mauricio R Loureiro-SilvaRoberto J Groszmann
May 1, 2007·Current Opinion in Critical Care·Gustavo Luiz BücheleDaniel De Backer
Mar 23, 2000·Journal of Hepatology·J Bosch, J C García-Pagán

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