A-to-I editing of coding and non-coding RNAs by ADARs

Nature Reviews. Molecular Cell Biology
Kazuko Nishikura


Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats. Editing of coding sequences can result in the expression of functionally altered proteins that are not encoded in the genome, whereas the significance of Alu editing remains largely unknown. Certain microRNA (miRNA) precursors are also edited, leading to reduced expression or altered function of mature miRNAs. Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.


Apr 20, 2016·Journal of the American Chemical Society·Matea HajnicBojan Zagrovic
Jun 15, 2016·Nucleic Acids Research·Giovanni NigitaCarlo M Croce
Jul 22, 2016·PLoS Genetics·Samantha B SheltonBlerta Xhemalce
Jun 29, 2016·RNA Biology·Thomas Philipp HoernesMatthias David Erlacher
Aug 16, 2016·Mobile DNA·John L Goodier
Oct 4, 2016·Briefings in Bioinformatics·David JohnShizuka Uchida
Oct 19, 2016·International Journal of Molecular Sciences·Caterina CatalanottoGiuseppe Zardo
Oct 5, 2016·Stress : the International Journal on the Biology of Stress·Li DaiWei-Jun Yang
Jan 5, 2017·ACS Chemical Biology·Jinghui Song, Chengqi Yi
Feb 2, 2017·Nature Reviews. Molecular Cell Biology·Cole J T LewisAuinash Kalsotra
Mar 10, 2017·DNA and Cell Biology·Lior GoldbergYael Nevo-Caspi
Apr 19, 2017·Nature Reviews. Cancer·Qingfei JiangCatriona H M Jamieson
Apr 25, 2017·Nature Structural & Molecular Biology·Masayuki SakuraiKazuko Nishikura
Jun 7, 2017·Nature Structural & Molecular Biology·Reyad A Elbarbary, Lynne E Maquat
Jan 20, 2017·Nature·Emily M HarcourtEric T Kool
Apr 8, 2017·Cell·Noa Liscovitch-BrauerEli Eisenberg
Jul 27, 2017·PLoS Genetics·Ilana BuchumenskiSebastian Kadener
Jul 27, 2017·Nature Reviews. Gastroenterology & Hepatology·Kazuko Nishikura
Mar 24, 2017·Bioinformatics·Jinkai WangYi Xing
Oct 20, 2017·Molecular Biology and Evolution·Yuange DuanJian Lu
Feb 21, 2018·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Peter A LarsenAnn M Saunders
Feb 6, 2018·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Elisa OrecchiniAlessandro Michienzi
Nov 8, 2017·International Journal of Molecular Sciences·Gabriele Romano, Lawrence N Kwong
Feb 1, 2018·Molecular Biology and Evolution·Zhen Liu, Jianzhi Zhang
Oct 3, 2017·Briefings in Bioinformatics·Li YaoYicheng Zhao
Aug 2, 2017·Antioxidants & Redox Signaling·Aikaterini GatsiouKonstantinos Stellos
Dec 22, 2017·Nucleic Acids Research·Valeriana CesariniAngela Gallo
Feb 28, 2018·Genes & Development·Daniel P ReichBrenda L Bass
Mar 2, 2018·Genes & Development·Amy E Pasquinelli
Apr 21, 2018·Annual Review of Immunology·Kwan T ChowYueh-Ming Loo
May 19, 2018·Nature Reviews. Drug Discovery·P Ann Boriack-SjodinRobert A Copeland
Nov 25, 2017·Nature Reviews. Cancer·Eleni AnastasiadouFrank J Slack
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Huiquan LiuJin-Rong Xu
Nov 25, 2017·Science·Li Yang, Ling-Ling Chen
Dec 20, 2017·Frontiers in Bioengineering and Biotechnology·Thomas Lissek
May 18, 2018·FEBS Letters·Galina Shevchenko, Kevin V Morris
Aug 19, 2017·RNA Biology·Nabeel S Ganem, Ayelet T Lamm


Feb 27, 1987·Cell·Brenda L Bass, H Weintraub
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R W WagnerKazuko Nishikura
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Egebjerg, S F Heinemann
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·U KimKazuko Nishikura
Feb 1, 1996·Nature·T MelcherM Higuchi
Dec 13, 1996·The Journal of Biological Chemistry·T MelcherPeter H Seeburg
May 15, 1997·Nature·C M BurnsRonald B Emeson
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A HerbertA Rich
May 20, 1999·Nature·S M RueterRonald B Emeson
Aug 10, 1999·Journal of Molecular Biology·K A Lehmann, B L Bass
Nov 28, 2000·Annual Review of Genetics·J M Gott, Ronald B Emeson
Aug 3, 2001·The EMBO Journal·A D J Scadden, C W Smith
Nov 12, 2002·The EMBO Journal·Leath A TonkinBrenda L Bass
Mar 6, 2003·The Journal of Biological Chemistry·Dan-Sung C ChoKazuko Nishikura
Apr 1, 2003·Journal of Cell Science·Joana M P DesterroMaria Carmo-Fonseca
May 2, 2003·The Journal of Biological Chemistry·Yutaka Kondo, Jean-Pierre J Issa
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christopher L SansamRonald B Emeson
Nov 14, 2003·The Journal of Biological Chemistry·Qingde WangKazuko Nishikura
Nov 15, 2003·The Journal of Biological Chemistry·Jochen C HartnerPeter H Seeburg
Dec 6, 2003·Science·Leath A Tonkin, Brenda L Bass
Feb 27, 2004·Nature·Yukio KawaharaShin Kwak
Jul 20, 2004·Nature Biotechnology·Erez Y LevanonMichael F Jantsch
Sep 3, 2004·Genome Research·Dennis D Y KimAbram Gabriel
Sep 14, 2004·Nature Structural & Molecular Biology·Tarun BhallaRobert Reenan
Nov 10, 2004·PLoS Biology·Alekos AthanasiadisStefan Maas
Nov 17, 2004·Genome Research·Matthew BlowMichael R Stratton
Feb 23, 2005·Current Biology : CB·Qiaoqiao WangGordon G Carmichael
Feb 26, 2005·Nucleic Acids Research·Erez Y LevanonEli Eisenberg
Mar 23, 2005·Nature Methods·Sébastien PfefferThomas Tuschl
May 17, 2005·Nature Structural & Molecular Biology·A D J Scadden
Jul 13, 2005·Cell·Carlo M Croce, George A Calin

Related Concepts

Regulation of RNA Interference
RNA, Untranslated
Regulation of Biological Process
RNA, Double-Stranded

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.