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A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

The Journal of Biological Chemistry

Mar 24, 2017

Masataka NakanoMiki Nakajima

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Abstract

Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine...read more

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  • A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

    The Journal of Biological Chemistry

    Mar 24, 2017

    Masataka NakanoMiki Nakajima

    PMID: 28188287

    DOI: 10.1074/jbc.m117.775684

    Abstract

    Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine...read more

    5
    4
    30

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