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A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

The Journal of Biological Chemistry

Feb 12, 2017

Masataka NakanoMiki Nakajima

Abstract

Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine...read more

Mentioned in this Paper

Study
Gene Expression Regulation, Neoplastic
Transfection
ADAR
Gene Knockdown Techniques
Adenosine
Enzymes, antithrombotic
Inosine
DHFR
RNA, Small Temporal
5
4
34
Paper Details
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A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

The Journal of Biological Chemistry

Feb 12, 2017

Masataka NakanoMiki Nakajima

PMID: 28188287

DOI: 10.1074/jbc.m117.775684

Abstract

Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine...read more

Mentioned in this Paper

Study
Gene Expression Regulation, Neoplastic
Transfection
ADAR
Gene Knockdown Techniques
Adenosine
Enzymes, antithrombotic
Inosine
DHFR
RNA, Small Temporal
5
4
34

Similar Papers Found In These Feeds

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

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Masataka NakanoMiki Nakajima
Paper Details
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  • Citations4
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