A topical azithromycin preparation for the treatment of acne vulgaris and rosacea

The Journal of Dermatological Treatment
R C McHughS R Feldman

Abstract

Erythromycin is a common therapy for acne and rosacea. A newer macrolide, azithromycin, offers superior tissue distribution and cellular concentration and is an effective oral anti-acne agent. Topical formulations such as erythromycin have been a major clinical therapy for acne. To date, no topical solution of azithromycin is available for the treatment of acne. To prepare a stable topical 2% azithromycin formulation that could be used in an acne clinical trial to determine the efficacy of topical azithromycin in treating subjects with acne vulgaris and acne rosacea. The study was divided into two phases. In phase I, azithromycin was prepared over a range of ethanol/water concentrations to determine solubility. The stability of a 2% azithromycin in 60% ethanol/water preparation was assessed by high-pressure liquid chromatography. The temperature, light, and pH dependence of the stability was also assessed. In phase II, a single center, randomized, double-blind, treatment-controlled study compared once-nightly application of topical 2% azithromycin versus 2% erythromycin. A total of 20 subjects with moderate inflammatory acne and 20 with rosacea were examined clinically at 0, 2, 4, 8, and 12 weeks for a 12-week period. Efficacy ...Continue Reading

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Citations

Mar 17, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lyle M BowmanMitchell Friedlaender
Mar 24, 2015·Journal of the American Academy of Dermatology·Dennis HopkinsonSteven R Feldman
May 12, 2016·Advanced Biomedical Research·Fatemeh MokhtariShadi Behfar
Mar 20, 2015·Drug Delivery and Translational Research·Shunmugaperumal TamilvananAshutosh Thakur
Aug 24, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·F AnzengruberA A Navarini
Nov 7, 2019·São Paulo Medical Journal = Revista Paulista De Medicina·Letícia Santos Berbert Faria Evaristo, Ediléia Bagatin
Jun 16, 2011·Lasers in Surgery and Medicine·Sachiko KosakaSeiji Kawana
Sep 20, 2011·Seminars in Cutaneous Medicine and Surgery·Jason EmerDiane Berson
Feb 4, 2021·Pharmaceutical Research·Muhammad Sohail ArshadZeeshan Ahmad

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