PMID: 6166002Apr 1, 1981Paper

A topographic gradient of molecules in retina can be used to identify neuron position

Proceedings of the National Academy of Sciences of the United States of America
G D TrislerM Nirenberg

Abstract

A monoclonal antibody was obtained that binds to cell membrane molecules distributed in a topographic gradient in avian retina. Thirty-five-fold more antigen was detected in dorsoposterior retina that in ventroanterior retina. Most of the antigen was associated with the synaptic layers of the retina. Less antigen was detected in cerebrum, thalamus, cerebellum, and optic tectum, but little or none was found in non-neural tissues tested. The antigen was found on most or all cell types in retina, and the concentration of antigen found is a function of the square of the circumferential distance from the ventroanterior pole of the gradient toward the dorsoposterior pole. Thus, the antigen can be used as a marker of cell position along the ventroanterior-dorsoposterior axis of the retina.

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Citations

Jan 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Z Kaprielian, P H Patterson
Jan 1, 1981·Biological cybernetics·A Gierer
Jan 1, 1988·Biological cybernetics·A Gierer
Jan 1, 1991·Anatomy and Embryology·D Nordquist, S C McLoon
Jan 1, 1987·Molecular Neurobiology·C J Barnstable
Nov 26, 1984·Brain Research·A De BlasH M Cherwinski
Jul 1, 1983·Developmental Biology·K WhiteL E Cannon
Mar 1, 1987·Cell Differentiation·B Pessac
Oct 1, 1987·Journal of Neuroscience Methods·C GravelR Hawkes
Nov 19, 1993·Brain Research. Developmental Brain Research·B SchlosshauerU Egert
Sep 1, 1991·Neuroscience Research·M Yamamoto, G Schwarting
Oct 1, 1992·Neuroscience Research·T MatsunoH Nakamura
Dec 1, 1992·Neuroscience Research·F MurakamiH Katsumaru
Feb 1, 1994·Neuroscience Research·T Matsuno, H Nakamura
Dec 1, 1992·Mechanisms of Development·B G JegalianE M De Robertis
Feb 1, 1993·Current Opinion in Neurobiology·J R Sanes
Dec 9, 1998·Neuropsychologia·R L Meyer
Jun 26, 2001·Brain Research. Brain Research Reviews·S Thanos, J Mey
Jun 28, 2001·Brain Research Bulletin·G Székely
Feb 1, 1997·Current Opinion in Neurobiology·U DrescherB K Müller
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W A ValenteL D Kohn
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R D McKay, S J Hockfield
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C FujitaS L Shotwell
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L A SternbergerN H Sternberger
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R HawkesA Matus
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Hockfield, R D McKay

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