A torque-based method demonstrates increased rigidity in Parkinson's disease during low-frequency stimulation.

Experimental Brain Research
Simon LittlePeter Brown

Abstract

Low-frequency oscillations in the basal ganglia are prominent in patients with Parkinson's disease off medication. Correlative and more recent interventional studies potentially implicate these rhythms in the pathophysiology of Parkinson's disease. However, effect sizes have generally been small and limited to bradykinesia. In this study, we investigate whether these effects extend to rigidity and are maintained in the on-medication state. We studied 24 sides in 12 patients on levodopa during bilateral stimulation of the STN at 5, 10, 20, 50, 130 Hz and in the off-stimulation state. Passive rigidity at the wrist was assessed clinically and with a torque-based mechanical device. Low-frequency stimulation at ≤20 Hz increased rigidity by 24 % overall (p = 0.035), whereas high-frequency stimulation (130 Hz) reduced rigidity by 18 % (p = 0.033). The effects of low-frequency stimulation (5, 10 and 20 Hz) were well correlated with each other for both flexion and extension (r = 0.725 ± SEM 0.016 and 0.568 ± 0.009, respectively). Clinical assessments were unable to show an effect of low-frequency stimulation but did show a significant effect at 130 Hz (p = 0.002). This study provides evidence consistent with a mechanistic link between o...Continue Reading

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Citations

Aug 31, 2017·Neurodegenerative Disease Management·Roongroj BhidayasiriChusak Thanawattano
Sep 5, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Zhimin LiRenzhi Wang
May 14, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Lazzaro di Biase, Alfonso Fasano
Jul 27, 2012·Annals of the New York Academy of Sciences·Simon Little, Peter Brown
Jul 31, 2021·Expert Review of Medical Devices·Bhavana PatelAdolfo Ramirez-Zamora

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Radionics Stereoplan
Statistical Program for Social Sciences ( SPSS )
SPSS

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