PMID: 8598542Mar 1, 1996Paper

A total parenteral nutrition solution supplemented with a nucleoside and nucleotide mixture sustains intestinal integrity, but does not stimulate intestinal function after massive bowel resection in rats

The Journal of Nutrition
S IijimaT Mori

Abstract

The effects of supplementing a total parenteral nutrition solution with a nucleoside and nucleotide mixture on mucosal adaptive processes after massive bowel resection were studied. Male Wistar rats (n=30) underwent 80% small intestine resection, were randomized into two groups and received either standard total parenteral nutrition (TPN) or TPN supplemented with a nucleoside and nucleotide mixture (2.5 mL.kg-1.d-1). An additional five rats, fed a nonpurified diet and not resected, were used as controls. After 4 or 7 d, rats were killed and samples were collected for mucosal indices and intestinal enzymatic activities (disaccharidases and diamine oxidase). After massive small bowel resection and TPN, residual jejunal mucosal wet weights, villus heights, protein and RNA contents on d 4 and 7, and total wet weights and DNA contents on d 7 were significantly lower than in the control group. Administration of the nucleoside and nucleotide mixture resulted in significantly higher residual jejunal total and mucosal weights, proteins, DNA, RNA contents, and the ratio of proliferating cell nuclear antigen positive cells per crypt than did the standard TPN solution on d 7. However, disaccharidase and diamine oxidase activities were not ...Continue Reading

Citations

Aug 19, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Mary E EvansThomas R Ziegler
Jun 1, 2011·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S J Dudrick, L Panait
Mar 7, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jennifer R Hess, Norman A Greenberg
Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaxia CaiYong Li

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