A tour of 3D genome with a focus on CTCF

Seminars in Cell & Developmental Biology
Diane C WangXiangdong Wang

Abstract

The complex three-dimensional (3D) structure of the genome plays critical roles in the maintenance of genome stability, organization, and dynamics and in regulation of gene expression for understanding molecular mechanisms and diseases. Chromatin maintains biological functions and transcriptional activities through long distance interaction and interactions between loops and enhancers-promoters. We firstly overview the architecture and biology of chromatin and loops, topologically associated domains (TADs) and interactions, and compartments and functions. We specifically focus on CCCTC-binding factor (CTCF) in 3D genome organization and function to furthermore understand the significance of CTCF biology, transcriptional regulations, interactions with cohesin, roles in DNA binding, influences of CTCF degradation, and communication with wings-apart like (Wapl) protein. We also summarize the advanced single cell approaches to further monitor dynamics of CTCF functions and structures in the maintenance of 3D genome organization and function at single cell level.

Citations

Feb 13, 2019·Cell Biology and Toxicology·Duojiao WuUNKNOWN CSGT group
Nov 15, 2020·International Journal of Molecular Sciences·Ashley Hall Nabec North American Brain Expression Consortium
Apr 4, 2021·International Journal of Molecular Sciences·Mohammed A Ibrahim Al-ObaideKalkunte S Srivenugopal

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