A Toxicological Evaluation of Chlamydomonas reinhardtii, a Green Algae

International Journal of Toxicology
Timothy S MurbachIlona Pasics Szakonyiné

Abstract

There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source is the green algae Chlamydomonas reinhardtii, the only green algae that has been studied as a model organism for many biological processes ranging from photosynthesis to flagellar movement. However, its potential as a safe nutritional source for use in various foods has not been thoroughly investigated. To assess the safety of C reinhardtii for use as a nutritional human food ingredient, in accordance with internationally accepted standards, the genotoxic potential and repeated-dose oral toxicity of the dried C reinhardtii (THN 6) algal biomass was investigated. The following studies were conducted: (1) a bacterial reverse mutation test, (2) an in vitro mammalian chromosomal aberration test, (3) an in vivo mammalian micronucleus test, and (4) a 28-day repeated-dose oral toxicity study in rats. No evidence of mutagenicity or genotoxic activity was observed in the first 3 tests under the applied test systems. In the 28-day study, male and female Hsd.Han Wistar rats were exposed to daily doses of 0, 1,000, 2,000, and 4,000 mg/kg bw by gavage. Following 28 days of continuous exposure, no mortality or treatment-re...Continue Reading

References

May 1, 1983·Mutation Research·D M Maron, B N Ames
Jun 1, 1980·Food and Cosmetics Toxicology·L V VenkataramanK R Mathew
Dec 13, 2000·Mutation Research·K Mortelmans, E Zeiger
May 5, 2001·Annual Review of Plant Physiology and Plant Molecular Biology·Elizabeth H Harris
Jun 16, 2005·Genetics·Thomas PröscholdAnnette W Coleman
Dec 19, 2006·Molecular Biotechnology·Christoph GriesbeckMarkus Heitzer
Oct 13, 2007·Science·Sabeeha S MerchantArthur R Grossman
Jul 8, 2009·Regulatory Toxicology and Pharmacology : RTP·Anthony G DayKerry S Howse
Apr 7, 2012·Regulatory Toxicology and Pharmacology : RTP·Nancy J SzaboPeter Licari
May 8, 2013·Current Opinion in Biotechnology·René H WijffelsKlaas J Hellingwerf
Jun 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nancy J SzaboTeresa Chan
Aug 16, 2014·Annals of the New York Academy of Sciences·Guoyao WuAnna E Thalacker-Mercer
Aug 20, 2014·AMB Express·Alma Lorena Almaraz-DelgadoJesús Agustín Badillo-Corona
Dec 18, 2014·Journal of Toxicologic Pathology·Darlene DixonMidori Yoshida
Feb 3, 2015·The Plant Journal : for Cell and Molecular Biology·Mark A ScaifeAlison G Smith
Nov 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Timothy S MurbachIlona Pasics Szakonyiné
May 2, 2017·Journal of Applied Phycology·Mark L WellsSusan H Brawley
May 20, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sayaka HimuroAkira Yasutake

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Citations

Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Laura StoffelsBrenda Parker
Jul 30, 2019·Journal of Toxicology·Timothy S MurbachIlona Pasics Szakonyiné
Jan 9, 2020·Journal of Toxicology·Timothy S MurbachIlona Pasics Szakonyiné
Jun 1, 2021·Frontiers in Plant Science·Karen Lizbeth Reyes-BarreraÁngel Gabriel Alpuche-Solís

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Methods Mentioned

BETA
chromosomal aberration
chromosomal aberrations

Software Mentioned

SPSS

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