PMID: 8606037Feb 1, 1996Paper

A toxicological review of topical exposure to white mineral oils

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J F NashA L Kraus

Abstract

White mineral oils have a long history of safe use by humans in orally ingested and topically applied products. A re-evaluation of the use of certain mineral hydrocarbons in the preparation of food items by regulators in the UK, however, has prompted additional safety studies and a critical assessment of the toxicological effects of white mineral oils. As white mineral oils are present in many topically applied drug and non-drug products, it is of interest to review the toxicological effects of mineral oil produced by this route of exposure. Specifically, the concern regarding the safety of white mineral oils has arisen, in part, from results of subchronic (e.g 90 day) feeding studies that reported the presence of granulomas in liver and histiocytosis in mesenteric lymph nodes of Fischer 344 rats after oral ingestion of select white mineral oils. In contrast to these subchronic oral studies, repeated topical exposure to white mineral oils has not been found to produce liver granulomas, histiocytosis in the mesenteric or other lymph nodes, or any local or systemic toxicity including tumour formation in Fischer 344 rates, C3H mice, New Zealand White rabbits or beagle dogs at similar or higher exposures (mg/kg/day). On the basis o...Continue Reading

References

Mar 1, 1992·Journal of the American Academy of Dermatology·R GhadiallyP M Elias
Aug 1, 1990·Journal of Applied Toxicology : JAT·R H McKeeC Chauzy
Aug 1, 1989·Journal of Applied Toxicology : JAT·R H McKeeR T Plutnick
Jan 1, 1989·Archives of Toxicology·R C Scott
Sep 1, 1987·Toxicology and Industrial Health·J J YangC R Mackerer
Aug 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R H McKeeL R DePass
Aug 1, 1970·Journal of Pharmaceutical Sciences·J N Bollinger
Dec 1, 1970·Biochimica Et Biophysica Acta·P W Albro, L Fishbein
Sep 1, 1966·Journal of Pharmaceutical Sciences·A G EbertS M Hess
Nov 1, 1962·Toxicology and Applied Pharmacology·P SHUBIKH RAMAHI
Feb 24, 1964·Biochimica Et Biophysica Acta·R D MCCARTHY
Sep 1, 1959·Toxicology and Applied Pharmacology·D C HERTINGR C CRAIN

❮ Previous
Next ❯

Citations

Aug 25, 2001·The British Journal of Nutrition·H CrewsG Williamson
Nov 30, 2006·International Journal of Toxicology·Shayne C GadHeide Robbe
Sep 19, 2012·Dermatology Research and Practice·Lorena S TelofskiGeorgios N Stamatas
Oct 6, 2011·Journal of Women's Health·Nicole ConcinKoni Grob
Jun 8, 2012·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J Zhang, R Qiu
Sep 22, 2012·International Journal of Cosmetic Science·A V Rawlings, K J Lombard
Aug 25, 2012·Autoimmunity·Sonja HermanMarkus H Hoffmann
Feb 26, 2014·International Journal of Toxicology·Walden E DalbeyRussell White
Nov 22, 2018·Environmental Monitoring and Assessment·Imad El-AlamAnissa Lounès-Hadj Sahraoui
Jan 16, 2020·Critical Reviews in Toxicology·Ralph PirowAndreas Luch
Oct 8, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B ChuberreA Barbaud
Jun 4, 2021·Scientific Reports·Kian Kun YapMarc Arthur Masen
May 29, 2021·Pest Management Science·Xénia PálfiKálmán Z Váczy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cosmetic Dermatology
Joseph C DiNardo
International Journal of Cosmetic Science
A V Rawlings, K J Lombard
British Medical Journal
J M KNOX, R OGURA
© 2021 Meta ULC. All rights reserved