A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma.

Oncoimmunology
Feng XuYongsong Chen

Abstract

The tumor-suppressor gene tumor protein p53 (TP53) is one of the most commonly mutated genes in human lung cancer, and TP53 mutations are associated with a worsened prognosis and causes resistance to cancer therapy. RNA sequencing and TP53 mutation data were downloaded to determine specific TP53-associated signature based on differentially expressed genes between patients with lung squamous cell carcinoma (LUSC) with wild type (TP53  WT) and mutated (TP53 MUT) TP53. We investigated the predictive value of this signature on the immune microenvironment, tumor mutational burden (TMB), and likelihood of response to immunotherapy and chemotherapy. In total, 1,556 differentially expressed genes were identified based on TP53 mutation status. Three genes (KLK6, MUC22 and CSN1S1) identified by univariate and multivariate Cox regression analyses, comprised the prognostic signature which was an independent and specific prognostic marker of overall survival in patients with LUSC. A nomogram was also established to validate this signature for clinical use. Moreover, the high-risk group was characterized by increased infiltration of monocytes and macrophages M1, and decreased T cells CD8 and T cells follicular helper. High-risk group exhibit...Continue Reading

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Citations

May 14, 2021·Frontiers in Oncology·Feng XuLing Lin
Jul 27, 2021·Computational and Mathematical Methods in Medicine·Yunping Lu

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Methods Mentioned

BETA
chips

Software Mentioned

R package “ edgeR
R package “ Genefilter
Cell type Identification by Estimating Relative Subsets of RNA...
VarScan
R package “ clusterProfiler ”
R package “ survival ”
GSEA
R
R package “ pRRophetic

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