PMID: 9653642Jul 8, 1998Paper

A transcriptional Map of the FMF region

Genomics
A BernotJ Weissenbach

Abstract

Familial Mediterranean fever (FMF) is a recessively inherited disorder characterized by attacks of fever and serositis, which affects primarily non-Ashkenazi Jews, Armenians, Turks, and Arabs. We present here a transcriptional map covering the FMF locus that we constructed in the course of the positional cloning of the gene responsible for this disease. This map was established from a contig constructed with YAC, BAC, and cosmid clones and covers about 500 kb of 16p13.3. It contains nine transcriptional units corresponding to known genes or to genes belonging to known gene families, 23 gene fragments characterized by partial sequences, and an endogenous retrovirus sequence. It thus considerably increases the number of genes in this interval and improves our knowledge concerning some of the genes or gene families present in this region. Data accumulated in this region were also used in a comparative study of different methods of exon detection.

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Citations

Aug 10, 2001·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·G Glusman, D Lancet
Sep 26, 2000·Molecular Genetics and Metabolism·M Telatar, W W Grody
Jan 17, 2003·European Journal of Human Genetics : EJHG·Micaela La ReginaRaffaele Manna
Oct 28, 2003·Clinical Chemistry·Isabelle Touitou
Feb 19, 1999·Biochimica Et Biophysica Acta·X ChenN Fischel-Ghodsian
May 25, 2021·Human Immunology·Anuradha Gautam, Bhaswati Pandit

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