A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord

Developmental Biology
Dominique BröhlCarmen Birchmeier

Abstract

Dorsal horn neurons express many different neuropeptides that modulate sensory perception like the sensation of pain. Inhibitory neurons of the dorsal horn derive from postmitotic neurons that express Pax2, Lbx1 and Lhx1/5, and diversify during maturation. In particular, fractions of maturing inhibitory neurons express various neuropeptides. We demonstrate here that a coordinate molecular mechanism determines inhibitory and peptidergic fate in the developing dorsal horn. A bHLH factor complex that contains Ptf1a acts as upstream regulator and initiates the expression of several downstream transcription factors in the future inhibitory neurons, of which Pax2 is known to determine the neurotransmitter phenotype. We demonstrate here that dynorphin, galanin, NPY, nociceptin and enkephalin expression depends on Ptf1a, indicating that these neuropeptides are expressed in inhibitory neurons. Furthermore, we show that Neurod1/2/6 and Lhx1/5, which act downstream of Ptf1a, control distinct aspects of peptidergic differentiation. In particular, the Neurod1/2/6 factors are essential for dynorphin and galanin expression, whereas the Lhx1/5 factors are essential for NPY expression. We conclude that a transcriptional network operates in matu...Continue Reading

References

Sep 1, 1990·Cellular and Molecular Neurobiology·M Otsuka, M Yanagisawa
Dec 1, 1981·The Journal of Physiology·A G Brown, R E Fyffe
Mar 3, 1995·Neuroscience Letters·D R SimmonsA J Todd
Jan 8, 1993·The Journal of Comparative Neurology·F ProudlockA J Todd
Dec 17, 1997·Developmental Biology·J C SzucsikS S Potter
Sep 15, 2001·Nature·P G Gillespie, R G Walker
Sep 15, 2001·Nature·D Julius, A I Basbaum
Nov 8, 2001·European Journal of Pharmacology·R Przewłocki, B Przewłocka
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Kin Ming Kwan, Richard R Behringer
Jun 8, 2002·Annual Review of Neuroscience·Ryuichi Shirasaki, Samuel L Pfaff
Jul 3, 2002·Nature Reviews. Neuroscience·Christo Goridis, Hermann Rohrer
Aug 20, 2002·Nature Genetics·Yoshiya KawaguchiChristopher V E Wright
Apr 3, 2003·Nature Reviews. Neuroscience·Tamara Caspary, Kathryn V Anderson
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tamar SapirMartyn Goulding
Jun 1, 1952·The Journal of Comparative Neurology·B REXED
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Mar 17, 2005·Genes & Development·Thomas MüllerCarmen Birchmeier
Jun 10, 2005·Neuropeptides·Zsuzsanna Wiesenfeld-HallinTomas Hökfelt
Jul 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shengguo LiMengqing Xiang
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anita JohnStefan Britsch
Dec 13, 2005·Current Opinion in Neurobiology·BinQuan Zhuang, Shanthini Sockanathan
May 23, 2006·Nature Neuroscience·Rumiko MizuguchiMartyn Goulding

❮ Previous
Next ❯

Citations

Jan 30, 2014·Nature Neuroscience·Steven A PrescottYves De Koninck
Sep 8, 2009·Neural Development·Patricia R Jusuf, William A Harris
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricia R JusufWilliam A Harris
Jul 12, 2011·Nature Neuroscience·Jeremy N KayJoshua R Sanes
Jan 31, 2015·Cell·Steeve BouraneMartyn Goulding
Oct 2, 2009·Peptides·Richard J Bodnar
Jun 21, 2011·Journal of Neuroscience Research·Chaquettea M Felton, Casonya M Johnson
Nov 20, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Debbie K Goode, Greg Elgar
Oct 31, 2015·Science·Steeve BouraneMartyn Goulding
Aug 11, 2015·Frontiers in Neural Circuits·John D ComerJulia A Kaltschmidt
May 26, 2015·Frontiers in Systems Neuroscience·Joseph L Bedont, Seth Blackshaw
May 4, 2013·Developmental Cell·Joshua C ChangJane E Johnson
Mar 28, 2013·Acta Biochimica Et Biophysica Sinica·Rui YanLeping Cheng
Mar 21, 2018·Nature Neuroscience·Jing HuangMark A Hoon
Oct 5, 2017·The European Journal of Neuroscience·Kazuhiko Nishida, Seiji Ito
Oct 6, 2016·Development·Helen C LaiJane E Johnson
Dec 18, 2010·Nature·Eric H Davidson
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Oct 27, 2015·Neural Development·Denise A Zannino, Charles G Sagerström
Dec 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Swapnali BardeTomas G M Hökfelt
Feb 7, 2019·Scientific Reports·Alexander PieperSandra Goebbels
Sep 30, 2017·Annual Review of Physiology·Stephanie C KochMartyn Goulding
Nov 27, 2019·Development·Andreas Sagner, James Briscoe
Apr 7, 2019·Current Opinion in Neurobiology·Graziana GattoMartyn Goulding

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.