A transcriptional study in mice with different ethanol-drinking profiles: possible involvement of the GABA(B) receptor

Pharmacology, Biochemistry, and Behavior
Andrea Frozino RibeiroA L Brunialti-Godard

Abstract

Previous studies have suggested that γ-aminobutyric acid-B (GABA(B)) receptor agonists effectively reduce ethanol intake. The quantification using real-time polymerase chain reaction of Gabbr1 and Gabbr2 mRNA from the prefrontal cortex, hypothalamus, hippocampus, and striatum in mice exposed to an animal model of the addiction developed in our laboratory was performed to evaluate the involvement of the GABA(B) receptor in ethanol consumption. We used outbred, Swiss mice exposed to a three-bottle free-choice model (water, 5% v/v ethanol, and 10% v/v ethanol) that consisted of four phases: acquisition (AC), withdrawal (W), reexposure (RE), and quinine-adulteration (AD). Based on individual ethanol intake, the mice were classified into three groups: "addicted" (A group; preference for ethanol and persistent consumption during all phases), "heavy" (H group; preference for ethanol and a reduction in ethanol intake in the AD phase compared to AC phase), and "light" (L group; preference for water during all phases). In the prefrontal cortex in the A group, we found high Gabbr1 and Gabbr2 transcription levels, with significantly higher Gabbr1 transcription levels compared with the C (ethanol-naive control mice), L, and H groups. In the...Continue Reading

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Citations

May 15, 2012·Pharmacology, Biochemistry, and Behavior·Gustavo Roberto Villas BoasRoseli Boerngen-Lacerda
Jul 15, 2016·Behavioural Brain Research·Daniel Almeida da Silva E SilvaAna Lúcia Brunialti Godard
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May 28, 2017·Journal of Neural Transmission·Andrea Frozino RibeiroAngela Maria Ribeiro
Sep 25, 2020·The International Journal of Neuropsychopharmacology·Eleonora GattaGraziano Pinna

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