A transient microenvironment loaded mainly with macrophages in the early developing human pancreas

The Journal of Endocrinology
L Banaei-BoucharebMichel Polak

Abstract

We have previously shown that the human developing pancreas, as a tissue under construction and remodeling, is composed of epithelial ducts and differentiated endocrine cells surrounded by mesenchyme. The physiologic importance of resident tissue leukocytes, expected to enter through the mesenchyme in remodeling functions, prompted us to investigate human developing pancreases for the presence of leukocyte lineages and for expression of cytokines and receptors involved in their recruitment and differentiation. Immunohistochemistry studies were performed on 69 human, paraffin-embedded pancreases at 6-12 weeks of development (WD). Cytokines and receptor transcripts were monitored by reverse transcription (RT)-PCR, by immunohistochemistry when antibodies were available or by in situ hybridization (ISH). We show that numerous cells expressing CD45RA, HLADR and CD68 antigens are cellular components of the mesenchyme of all the pancreases at 6-12 WD. So-called constitutive chemokines (SLC (CCL19), stromal-derived factor 1 (SDF1) (CXCL12)) and a macrophage-specific growth/survival factor, colony-stimulating factor 1 (CSF1), were detected in epithelial duct cells. Both epithelial and mesenchymal cells expressed chemokine receptors, sug...Continue Reading

Citations

Sep 15, 2010·Cancer Metastasis Reviews·Leanne C Huysentruyt, Thomas N Seyfried
Aug 13, 2011·ASN Neuro·Leanne C HuysentruytThomas N Seyfried
Apr 9, 2013·Respiratory Research·Christina V JonesSharon D Ricardo
Feb 20, 2016·Diabetologia·Piero Marchetti
Aug 13, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Zachary N AgricolaAlan P Kenny
Sep 6, 2011·Trends in Molecular Medicine·James A StefaterJeremy S Duffield
Apr 10, 2008·International Journal of Cancer. Journal International Du Cancer·Leanne C HuysentruytThomas N Seyfried
Sep 11, 2008·Genesis : the Journal of Genetics and Development·Dmitry A Ovchinnikov
Sep 18, 2013·Diabetes, Obesity & Metabolism·K Eguchi, I Manabe
Mar 22, 2016·Expert Review of Clinical Immunology·Roberto GiacomelliPaola Cipriani
Jun 11, 2014·The International Journal of Biochemistry & Cell Biology·Xiaocang CaoQiang Liu
Aug 27, 2013·Organogenesis·Christina V Jones, Sharon D Ricardo
Jan 10, 2014·Diabetes & Metabolism Journal·Cesar Corzo, Patrick R Griffin
Oct 18, 2014·International Immunology·Naomi McGovernFlorent Ginhoux
May 23, 2015·Molecular Endocrinology·David L Morris
Sep 1, 2016·American Journal of Physiology. Endocrinology and Metabolism·David C WoodlandXiaojuan Chen
Sep 5, 2020·Immunity, Inflammation and Disease·Andrea F CruzFarzad Esni
Nov 2, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Valerie Curtis
Jan 4, 2017·The Journal of Clinical Investigation·Kosei Eguchi, Ryozo Nagai
Aug 25, 2018·Nature Reviews. Immunology·Christopher Z W LeeFlorent Ginhoux
Apr 17, 2019·Seminars in Immunopathology·Marianne Böni-Schnetzler, Daniel T Meier
May 10, 2020·Science·Jong-Eun ParkMuzlifah Haniffa
Jan 12, 2021·Trends in Immunology·Mitchell Bijnen, Marc Bajénoff
Mar 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wan-Jiao GaoHua Zhou
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Mohi MiahMuzlifah Haniffa
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers
Oct 19, 2020·Pediatric Research·Olachi J Mezu-Ndubuisi, Akhil Maheshwari
May 18, 2020·Seminars in Cell & Developmental Biology·Piero MarchettiLorella Marselli

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