A Transitional Probability Model for Parkinson's Disease Motor States With Applications to Missing Data

Therapeutic Innovation & Regulatory Science
Phillip Dinh

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder with significant disability. Subjects with advanced PD often suffer from motor complications that may interfere significantly with their daily activities. Levodopa (LD) in combination with a dopa decarboxylase inhibitor such as carbidopa (CD) is considered the gold standard in the treatment of PD. However, long-term treatment with LD often leads to the development of motor complications. Motor complications include motor fluctuations and dyskinesia. Motor fluctuations are states where the subject cycles between periods of "on" state where subjects are in improved mobility and "off" state where subjects are in impaired mobility. Dyskinesia are the involuntary and irregular twisting and/or turning movements. A Markov transitional probability model is proposed to estimate the likelihood of staying in one state versus transitioning from one state to another. An application of the model to an example from a clinical trial investigating the effect of an extended-release carbidopa-levodopa (CD-LD) product versus an immediate-release CD-LD product is illustrated. A Markov transitional probability model can be used to model the likelihood of staying in one state versus...Continue Reading

References

Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·A J Lees
Oct 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·F A Sonnenberg, J R Beck
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Robert A HauserPhilippe Lehert
Nov 29, 2007·Pharmacotherapy·Mark Lew
Dec 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daron AcemogluKonstantin Sonin
Oct 9, 2015·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Theodoros MantopoulosLazaros Andronis

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