A Translation Tuning HuDdle for Neurons

Molecular Cell
Mary McMahon, Davide Ruggero

Abstract

In this issue of Molecular Cell, Tebaldi et al. (2018) identify the neuron-specific RNA-binding protein HuD as a regulator of global protein synthesis and translation enhancer of specific mTORC1-responsive transcripts. Importantly, the authors identify that the Y3 small non-coding RNA binds HuD to modulate translation and neurogenesis.

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