PMID: 9169964Jun 1, 1997Paper

A treatment for tardive dyskinesia and some other extrapyramidal symptoms

Journal of Clinical Psychopharmacology
M A CowenK Abbott

Abstract

The effects of the administration of acetazolamide and thiamine (A + T) on the symptoms of tardive dyskinesia (TD) and parkinsonism of 8 elderly and 25 younger chronic hospitalized mental patients were examined in a placebo-controlled, double-blind, counterbalanced two-period cross-over study with initial baselines and intervening washout periods. All patients were maintained on their prestudy psychoactive and anti-Parkinson medications, without alteration, throughout the study. The elderly group received 1.5 g acetazolamide and thiamine per day in three divided doses for 3 weeks. The younger group received 1.5 g thiamine and 2.0 g acetazolamide per day in divided doses for 2 months. Both groups showed a significant decrease in scores on the Abnormal Involuntary Movement Scale (TD) and the Simpson-Angus Neurological Rating Scale (parkinsonism) while on A + T. The A + T effects were unrelated to age, gender, diagnosis, or maintenance medications.

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Citations

Feb 19, 2002·Neurochemistry International·Gary E Gibson, Hui Zhang
Oct 8, 1999·Trends in Cell Biology·H F TabakB Distel
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Apr 5, 2020·International Journal of Molecular Sciences·Jyoti Singh Tomar, Jun Shen
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