A triage strategy in advanced ovarian cancer management based on multiple predictive models for R0 resection: a prospective cohort study

Journal of Gynecologic Oncology
Zheng FengXiaohua Wu

Abstract

To present the surgical outcomes of advanced epithelial ovarian cancer (AEOC) since the implementation of a personalized approach and to validate multiple predictive models for R0 resection. Personalized strategies included: 1) Non-invasive model: preoperative clinico-radiological assessment according to Suidan criteria with a predictive score for all individuals. Patients with a score 0-2 were recommended for primary debulking surgery (PDS, group A), or otherwise were counseled on the choices of PDS, neoadjuvant chemotherapy (NAC, group B) or staging laparoscopy (S-LPS). 2) Minimally invasive model: S-LPS with a predictive index value (PIV) according to Fagotti. Individuals with a PIV <8 underwent PDS (group C) or otherwise received NAC (group D). Intraoperative assessment (with Eisenkop, peritoneal cancer index [PCI], and Aletti scores) and surgical results were prospectively collected. Between September 2015 and August 2017, 161 pathologically confirmed epithelial ovarian cancer patients were included. A total of 52 (32.3%) patients had a predictive score of 0-2, and 109 (67.7%) patients had a score ≥3. Among these individuals, 41 (25.5%) patients received S-LPS. Finally, 110 (68.3%) patients underwent PDS (A+C), and 51 (31....Continue Reading

References

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Sep 8, 2010·The New England Journal of Medicine·Ignace VergoteUNKNOWN NCIC Clinical Trials Group
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Dec 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne J RuttenMarrije R Buist

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Citations

Mar 22, 2019·Medicine·Renata RaśKrzysztof Gutkowski
May 2, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Stefano GreggiAntonio Gonzalez Martin
Aug 23, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fabio CarboniMario Valle
Apr 6, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M P EngbersenW J Van Driel
Apr 16, 2021·Scientific Reports·Antoni LluecaUNKNOWN MUAPOS working group (Multidisciplinary Unit of Abdominal Pelvic Oncology Surgery)

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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