A trial of fresh autologous whole blood to treat dilutional coagulopathy following cardiopulmonary bypass in infants

Paediatric Anaesthesia
Robert H FriesenRichard M Friesen

Abstract

Transfusion of fresh whole blood is superior to blood component therapy in correcting coagulopathies in children following cardiopulmonary bypass (CPB); however, a supply of fresh homologous whole blood is difficult to maintain. We hypothesized that transfusion of fresh autologous whole blood obtained prior to heparinization for CPB and infused following CPB would be associated with improved coagulation function when compared with standard therapy. A total of 32 infants 5-12 kg undergoing noncomplex open cardiac surgery were randomly assigned to either the treatment or control group. In the treatment group, 15 ml x kg(-1) of autologous whole blood was collected into a CPDA bag prior to heparinization while 15 ml x kg(-1) of 5% albumin was infused intravenously. After reversal of heparin, coagulation tests were drawn in both groups, and the autologous whole blood was infused over 20 min in the treatment group. The treatment group had greater (P < 0.05) improvement in platelet count, prothrombin time, and fibrinogen than the control group. We conclude that collection of fresh autologous whole blood prior to heparinization and reinfusion following CPB is associated with greater improvement of coagulation status after CPB in infants.

References

Sep 1, 1992·The Annals of Thoracic Surgery·F H KernP R Hickey
Dec 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·B D Spiess
Aug 1, 1985·Journal of Pediatric Surgery·N S AdzickD M Fisher
May 29, 1986·The New England Journal of Medicine·L A Harker
Aug 1, 1995·Anesthesia and Analgesia·S T HiippalaE M Vahtera
Dec 1, 1996·Anesthesia and Analgesia·C C D'ErricoE L Bove
Jan 22, 1998·The Annals of Thoracic Surgery·R H FriesenM A Tornabene
Mar 2, 1999·British Journal of Haematology·D H Bevan
Feb 28, 2003·The Annals of Thoracic Surgery·Irving ShenRoss M Ungerleider
Apr 24, 2004·Anesthesia and Analgesia·Michael J EissesWayne L Chandler

❮ Previous
Next ❯

Citations

Aug 26, 2009·Anesthesiology Clinics·Shilpa VermaMichael Richards
Nov 8, 2007·Paediatric Anaesthesia·Angus McEwan
Aug 28, 2010·Transfusion·Jeremy G PerkinsUNKNOWN 31st Combat Support Hospital Research Group
Feb 12, 2011·Transfusion·Richard Kaufman
Mar 31, 2015·The Annals of Thoracic Surgery·David R JobesDavid Friedman
May 15, 2012·The Journal of Thoracic and Cardiovascular Surgery·Roberta J NavickisMahlon M Wilkes
Mar 6, 2018·Acta Anaesthesiologica Scandinavica·W M CresciniM M Treggiari
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Mar 20, 2019·Transfusion·Deborah Sesok-PizziniDavid Jobes
Jul 11, 2020·World Journal for Pediatric & Congenital Heart Surgery·Weronika M HarrisIrving Shen
Nov 11, 2020·Seminars in Thoracic and Cardiovascular Surgery·Manan Desai, Can Yerebakan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.