A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.

The New England Journal of Medicine
Bin CaoChen Wang

Abstract

No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) of less than 300 mm Hg. Patients were randomly assigned in a 1:1 ratio to receive either lopinavir-ritonavir (400 mg and 100 mg, respectively) twice a day for 14 days, in addition to standard care, or standard care alone. The primary end point was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a seven-category ordinal scale or discharge from the hospital, whichever came first. A total of 199 patients with laboratory-confirmed SARS-CoV-2 infection underwent randomization; 99 were assigned to the lopinavir-ritonavir group, and 100 to the standard-care group. Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical ...Continue Reading

Associated Clinical Trials

Apr 20, 2020·Gian Paolo Rossi, MD, FAHA, FACC
Jun 1, 2020·Amit Singla, MD, FAANS

References

May 18, 2004·Biochemical and Biophysical Research Communications·Norio YamamotoNaoki Yamamoto
Jul 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yi WuChi-Huey Wong
Aug 4, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·F ChenK Y Yuen
Jul 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janice K LouieTimothy M Uyeki
Oct 8, 2013·The Journal of Infection·Jasper F W ChanKwok-Yung Yuen
Oct 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeremy KatzenMichael G Ison
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 20, 2020·The New England Journal of Medicine·Lirong ZouJie Wu

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Citations

Mar 19, 2020·The New England Journal of Medicine·Lindsey R Baden, Eric J Rubin
Apr 3, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bruno Mégarbane
Apr 8, 2020·Circulation Research·Akbarshakh Akhmerov, Eduardo Marban
Apr 11, 2020·The New England Journal of Medicine·Jonathan GreinTimothy Flanigan
Apr 15, 2020·The New England Journal of Medicine·Benjamin N Rome, Jerry Avorn
Apr 5, 2020·Journal of Clinical Medicine·Pietro H GuzziFederico M Giorgi
Apr 17, 2020·Clinical Pediatrics·Priyank J YagnikPooja H Desai
Apr 16, 2020·Pharmaceuticals·Jean Jacques Vanden Eynde
Apr 25, 2020·The New England Journal of Medicine·Rajesh T GandhiCarlos Del Rio
Apr 3, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Pedram Ahmadpoor, Lionel Rostaing
Apr 28, 2020·Indian Journal of Pediatrics·Jhuma SankarRakesh Lodha
Apr 14, 2020·International Journal of Rheumatic Diseases·Sanket ShahVir Singh Negi
Apr 7, 2020·Sports Health·Brett G Toresdahl, Irfan M Asif
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Deborah J CookRobert A Fowler
Apr 29, 2020·Journal of Primary Care & Community Health·Zach Sartor, Burritt Hess
Apr 6, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Liona C PoonMoshe Hod
Apr 30, 2020·International Reviews of Immunology·Alex ShneiderAnna Vakhrusheva
May 1, 2020·Nature·Heidi Ledford
May 5, 2020·Microbial Biotechnology·Harald Brüssow
Apr 23, 2020·Journal of the Pediatric Infectious Diseases Society·Kathleen ChiotosMari M Nakamura
Apr 9, 2020·Pharmacotherapy·Kathleen A StringerRobert P Dickson
May 6, 2020·The New England Journal of Medicine·Daniel Havlichek
May 7, 2020·The Medical Journal of Australia·Jennifer H Martin, Nikola A Bowden
Apr 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean NachegaAlimuddin Zumla
Apr 8, 2020·Pharmacotherapy·Ashley BarlowMojdeh S Heavner
Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge
May 13, 2020·Journal of Cellular Physiology·Bahman YousefiMajid Eslami
May 6, 2020·Pediatric Research·Damian Roland, Brian K Stansfield
Apr 30, 2020·Journal of Internal Medicine·Giuseppe PascarellaFelice Eugenio Agrò
May 15, 2020·Journal of Orthopaedic Surgery·Colin Shing-Yat YungYat Wa Wong
May 16, 2020·The New England Journal of Medicine·David A BerlinFernando J Martinez
Apr 9, 2020·Pharmacotherapy·Thomas P Lodise, Michael J Rybak
Apr 25, 2020·British Journal of Pharmacology·Cristina ScavoneAnnalisa Capuano
Apr 9, 2020·QJM : Monthly Journal of the Association of Physicians·K K SahuA Lal
Apr 17, 2020·Journal of Thrombosis and Thrombolysis·Richard C Becker
Apr 18, 2020·Annals of the Rheumatic Diseases·Iain B McInnes
May 23, 2020·Journal of Clinical Pharmacology·Luca GallelliFenghua Fu
May 8, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Luise HolzhauserAnn B Nguyen
May 23, 2020·PLoS Pathogens·Daolin TangRui Kang
May 6, 2020·Journal of Medical Virology·Jialin Liu, Siru Liu
May 28, 2020·The New England Journal of Medicine·Jason D GoldmanUNKNOWN GS-US-540-5773 Investigators

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Clinical Trials Mentioned

NCT02845843

Software Mentioned

SAS

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