Abstract
The primary objective was to investigate the safety of recombinant human granulocyte colony stimulating factor (rhG-CSF) for the treatment of very low birthweight infants (VLBW) with sepsis and relative neutropenia, specifically with regard to worsening of respiratory distress and thrombocytopenia and all cause mortality. Secondary objectives were to evaluate duration of ventilation, intensive care, and antibiotic use as markers of efficacy. Neonates (< or = 28 days) in intensive care, with birth weights of 500-1500 g, absolute neutrophil count (ANC) of < or = 5 x 10(9)/l, and clinical evidence of sepsis, were randomly assigned to receive either rhG-CSF (10 microg/kg/day) administered intravenously (n = 13), or placebo (n = 15) for a maximum of 14 days, in addition to standard treatment and antibiotics. All adverse events, oxygenation index, incidence of thrombocytopenia, all cause mortality, duration of ventilation, intensive care and antibiotic treatment, and ANC recovery were compared between the two groups. Adverse events and oxygenation index were not increased by, and thrombocytopenia was not attributable to, treatment with rhG-CSF. At 6 and 12 months postmenstrual age, there were significantly fewer deaths in the group r...Continue Reading
References
Jul 1, 1979·The Journal of Pediatrics·B L ManroeR Browne
Jun 11, 1976·The Journal of Pediatrics·J J HutterE R Wayne
Jul 1, 1992·Archives of Disease in Childhood
Oct 1, 1972·Archives of Disease in Childhood·J Gregory, E Hey
Feb 1, 1980·The Journal of Pediatrics·R D Christensen, G Rothstein
Jan 22, 1982·JAMA : the Journal of the American Medical Association·A G Philip
Jan 1, 1982·Biology of the Neonate·S H ErdmanG Rothstein
Sep 1, 1994·Blood·E R GillanM S Cairo
Jan 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·A R RussellE Gordon-Smith
May 1, 1995·Pediatric Research·A R Bedford RussellE C Gordon-Smith
Oct 1, 1994·The Journal of Pediatrics·R L SchelonkaJ Butler
May 1, 1993·The Pediatric Infectious Disease Journal·R L RodwellP H Gray
Jul 1, 1993·Archives of Disease in Childhood·S ArnonM Silverman
Oct 1, 1993·The Journal of Pediatrics·X Sáez-Llorens, G H McCracken
Jul 1, 1996·The Journal of Pediatrics·B J StollL L Wright
Jul 1, 1996·The Journal of Pediatrics·B J StollL L Wright
Sep 1, 1996·Pediatric Research·S H MurchT T MacDonald
Jul 1, 1997·Pediatrics·S G HassinkV L Funanage
May 8, 1998·The New England Journal of Medicine·S B Levy
Jul 4, 1998·Pediatrics·K R SchiblerD D Thompson
Jul 17, 1998·Current Opinion in Hematology·F BrachoM S Cairo
Aug 1, 1998·European Journal of Pediatrics·V Drossou-AgakidouG Kremenopoulos
Oct 31, 1998·Pediatrics·P Kocherlakota, E F La Gamma
Dec 10, 1999·Pediatrics·D D MarshallT M O'Shea
Citations
May 12, 2005·Bioorganic & Medicinal Chemistry·Ai-Ying DuJun-Ying Miao
Mar 7, 2002·Current Opinion in Pediatrics·Hilton M BernsteinRobert D Christensen
Mar 18, 2003·Current Opinion in Pediatrics·Mandhir SuriMitchell S Cairo
Nov 16, 2004·Critical Care Medicine·Juan C Gea-BanaclocheCatherine Cordonnier
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph A Carcillo
Dec 11, 2013·Current Opinion in Hematology·Akhil Maheshwari
Feb 23, 2007·International Journal of Clinical Practice·C K ShawK Malla
Feb 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·N A Murray, I A G Roberts
Oct 20, 2004·BMC Infectious Diseases·Emine AlpMehmet Doganay
Feb 7, 2004·Pediatric Research·Jason A GerstingDarlene A Calhoun
May 27, 2009·The Journal of Pediatrics·Pierre KuhnDominique Astruc
Nov 15, 2002·Pediatric Clinics of North America·Wade Kyono, Thomas D Coates
Apr 6, 2012·Pediatric Hematology and Oncology·Mona M El-GanzouryInji G El-Sherbini
Mar 7, 2006·Neonatal Network : NN·Susan Givens Bell
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R CarrC Doré
Mar 24, 2004·Acta Paediatrica. Supplement·R Carr, N Modi
Dec 13, 2002·Acta Paediatrica. Supplement·E F La Gamma, M H De Castro
Jan 25, 2003·Critical Care Medicine·Thomas HartungEugen Faist
Feb 18, 2003·Scandinavian Journal of Infectious Diseases·Sükrü KücüködükDavut Albayrak
Aug 7, 2019·BMC Pediatrics·Yuhang LiChangsong Wang
Mar 5, 2020·Revista da Associação Médica Brasileira·Antonio SilvinatoGabriel Nogueira Bastos Soledade