PMID: 7011362Mar 1, 1981Paper

A trial of the effects of soya-bean flour and soya-bean saponins on plasma lipids, faecal bile acids and neutral sterols in hypercholesterolaemic men

The British Journal of Nutrition
G D CalvertJ D Potter

Abstract

1. The hypothesis that soya-bean saponins, by binding bile salts in the gastrointestinal lumen, are responsible for some of the plasma-cholesterol-lowering effect of soya-bean preparations, was tested. In a double-blind crossover study 50 g soya-bean flour/d, containing either 22 or 4 g saponins/kg (adjusted by ethanol extraction) was incorporated in biscuits as a substitute for biscuits or bread into the diet of ten outpatient hypercholesterolaemic men over two consecutive 4-week study periods. The diet was monitored to ensure constancy, saponin-rich foods excluded, faeces collected for bile acid and neutral sterol analysis, and blood taken for plasma lipoprotein lipid analysis. 2. Neither diet had any effect on cholesterol in any plasma lipoprotein fraction, on fasting plasma triglyceride, or on faecal bile acids and neutral sterols. 3. These results suggested that soya-bean saponins are not responsible for the hypocholesterolaemic effect of soya-bean products.

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Citations

Dec 19, 2002·Journal of the American Dietetic Association·Arrigo F G CiceroAntonio Gaddi
Dec 21, 2002·The British Journal of Nutrition·George FrancisKlaus Becker
Feb 13, 2013·Journal of Medicinal Food·Malika Bouchenak, Myriem Lamri-Senhadji
Jan 1, 1991·Nutrition Research Reviews·S M Kingman
Oct 1, 1995·Plant Foods for Human Nutrition·M A Zulet, J A Martinez
Feb 15, 1988·Klinische Wochenschrift·C A Barth, M Pfeuffer
May 18, 2010·Journal of Ethnopharmacology·Adejuwon Adewale AdeneyeEsther Oluwatoyin Agbaje
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S AnthonyJ D Wagner
Mar 1, 2006·International Journal of Food Sciences and Nutrition·D M GurfinkelA V Rao
Nov 1, 1985·Digestive Diseases and Sciences·M Ponz de LeonN Carulli
Jan 1, 1987·Critical Reviews in Food Science and Nutrition·K R PriceG R Fenwick
Sep 26, 2013·Plant Foods for Human Nutrition·Rocio A Chávez-SantoscoySergio O Serna-Saldívar
Sep 1, 1983·Atherosclerosis·D G Oakenfull, D L Topping
Oct 1, 1982·Pharmacological Research Communications·G NosedaC R Sirtori
Sep 6, 2007·Journal of Agricultural and Food Chemistry·Simone Rochfort, Joe Panozzo

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