A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.

PloS One
Cheikh SokhnaJean-François Trape

Abstract

In the Sahel, most malaria deaths occur among children 1-4 years old during a short transmission season. A trial of seasonal intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) and a single dose of artesunate (AS) showed an 86% reduction in the incidence of malaria in Senegal but this may not be the optimum regimen. We compared this regimen with three alternatives. 2102 children aged 6-59 months received either one dose of SP plus one dose of AS (SP+1AS) (the previous regimen), one dose of SP plus 3 daily doses of AS (SP+3AS), one dose of SP plus three daily doses of amodiaquine (AQ) (SP+3AQ) or 3 daily doses of AQ and AS (3AQ+3AS). Treatments were given once a month on three occasions during the malaria transmission season. The primary end point was incidence of clinical malaria. Secondary end-points were incidence of adverse events, mean haemoglobin concentration and prevalence of parasites carrying markers of resistance to SP. The incidence of malaria, and the prevalence of parasitaemia at the end of the transmission season, were lowest in the group that received SP+3AQ: 10% of children in the group that received SP+1AS had malaria, compared to 9% in the SP+3AS group (hazard ratio HR 0.90, 95%CI 0.60,...Continue Reading

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Citations

Nov 16, 2010·Bulletin of the World Health Organization·Ilona CarneiroDavid Schellenberg
Sep 11, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Matthew CairnsDaniel Chandramohan
Jan 13, 2010·Antimicrobial Agents and Chemotherapy·M CairnsP J M Milligan
Sep 26, 2013·International Journal of Epidemiology·Valerie DelaunayCheikh Sokhna
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Jun 30, 2009·Tropical Medicine & International Health : TM & IH·R D GoslingD Chandramohan
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May 1, 2015·PLoS Neglected Tropical Diseases·Márcia Almeida Araújo AlexandreMaria das Graças Costa Alecrim
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Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

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