PMID: 11341547May 9, 2001Paper

A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples

Industrial Health
S AdachiK Takemoto

Abstract

We tried to evaluate the carcinogenic risk of man-made mineral fiber based on the mesothelioma incidence in female F344 rats after intraperitoneal administration. Rats (female F344/ Nslc, 5-week-old, n=330) were observed for 2 years after the intraperitoneal administration of 5 to 20 mg of 9 types of the JFM (Japan Fibrous Material Research Association) standard fiber samples (glass wool, rock wool, micro fiber glass, three types of refractory fiber, potassium titanate whisker, silicon carbide whisker, titanium oxide whisker), wollastonite (natural fiber) and UICC chrysotile B. All rats administered 10 mg of silicon carbide whisker had developed peritoneal mesothelioma within a year. The cumulative incidence of peritoneal mesothelioma at the end of the experiment was 85% for 10 mg UICC chrysotile B, 77% for 10 mg of potassium titanate whisker, 70% for 5 mg of silicon carbide whisker, 20% for 5 mg of potassium titanate whisker, 20% for 20 mg of refractory fiber 2 and 10% for 20 mg of refractory fiber 1. Carcinogenicity was estimated 2.4 times for silicon carbide whisker and 0.23 for potassium titanate whisker in comparison with UICC chrysotile B. It has been well documented from several experimental studies that man-made fibers ...Continue Reading

Citations

Apr 26, 2006·Journal of Industrial Microbiology & Biotechnology·Naoto Yoshida, Kazuki Takebe
Oct 20, 2005·Journal of Bioscience and Bioengineering·Naoto Yoshida, Yuichi Saeki
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Melisa Bunderson-SchelvanAndrij Holian
Dec 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroyuki TsudaJun Kanno
Jul 16, 2005·Inhalation Toxicology·L Daniel Maxim, E E McConnell
Mar 10, 2010·Journal of Biomedical Materials Research. Part a·Yang-Jo SeolSang-Hoon Rhee
Dec 21, 2005·Mutation Research·J b TopinkaP Georgiadis
May 31, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David B Warheit, Leonard S Levy

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