A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response

Molecular Cancer Therapeutics
Mariana MalviciniGuillermo Mazzolini

Abstract

In colorectal carcinoma patients, distant metastatic disease is present at initial diagnosis in nearly 25% of them. The majority of patients with metastatic colorectal carcinoma have incurable disease; therefore, new therapies are needed. Agents derived from medicinal plants have already demonstrated therapeutic activities in human cancer cells. Antartina is an antitumor agent isolated from Deschampsia antarctica Desv. This study aimed to evaluate the antitumor properties of Antartina in colorectal carcinoma models. We used human and murine colorectal carcinoma cell lines for investigating proliferation, apoptosis, and cell-cycle effects of Antartina therapy in vitro Avatar and immunocompetent colorectal carcinoma animal models were applied for evaluating the effects of Antartina in vivo Immune response against colorectal carcinoma model was investigated using CTL assay, analyzing dendritic cell activation and intratumor T-cell subpopulation, and by tumor rechallenge experiments. Antartina inhibits in vitro human colorectal carcinoma cell proliferation; however, in vivo experiments in Avatar colorectal carcinoma model Antartina display a limited antitumor effect. In an immunocompetent colorectal carcinoma mice model, Antartina ...Continue Reading

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Citations

Sep 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joo-Myung MoonSeun-Ah Yang
Jan 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jorge O ChiapellaJosef Greimler
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Grace Gar-Lee YueClara Bik-San Lau
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jia-Xin LiPei-Yu Yan
Nov 10, 2021·CA: a Cancer Journal for Clinicians·Jun J MaoLuis Alejandro Salicrup

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