A TRIFfic perspective on acute lung injury.

Cell
Thomas R Martin, Mark M Wurfel

Abstract

Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.

References

May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C SittipuntT R Martin
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Feb 8, 2006·Annual Review of Physiology·Claudia C dos Santos, Arthur S Slutsky
Mar 4, 2006·American Journal of Respiratory and Critical Care Medicine·Stephanie NonasKonstantin G Birukov
Aug 29, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shawn J SkerrettAdeline M Hajjar
Aug 24, 2007·Advances in Experimental Medicine and Biology·Joost J OppenheimDe Yang
Dec 27, 2008·Cell·Kenichiro ImaiPaul Horton

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Citations

Oct 12, 2011·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yumiko Imai
Nov 12, 2009·European Journal of Immunology·Heng ZhengRuxana T Sadikot
Nov 5, 2010·The Journal of General Virology·Takuya ShiozakiTadaaki Miyazaki
Apr 13, 2012·Journal of Biomedicine & Biotechnology·Feixiang WuWeifeng Yu
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vafa Baradaran RahimiVahid Reza Askari
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi ZhangPatty J Lee
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenyang WeiYu He

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Methods Mentioned

BETA
lavage

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