A TRIM insertion in the promoter of Ms2 causes male sterility in wheat

Nature Communications
Chuan XiaXiuying Kong

Abstract

The male-sterile ms2 mutant has been known for 40 years and has become extremely important in the commercial production of wheat. However, the gene responsible for this phenotype has remained unknown. Here we report the map-based cloning of the Ms2 gene. The Ms2 locus is remarkable in several ways that have implications in basic biology. Beyond having no functional annotation, barely detectable transcription in fertile wild-type wheat plants, and accumulated destructive mutations in Ms2 orthologs, the Ms2 allele in the ms2 mutant has acquired a terminal-repeat retrotransposon in miniature (TRIM) element in its promoter. This TRIM element is responsible for the anther-specific Ms2 activation that confers male sterility. The identification of Ms2 not only unravels the genetic basis of a historically important breeding trait, but also shows an example of how a TRIM element insertion near a gene can contribute to genetic novelty and phenotypic plasticity.

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Citations

Jan 24, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Awais Rasheed, Xianchun Xia
Nov 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zheng WangLigeng Ma
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Datasets Mentioned

BETA
KY238200-KY238284
GFFI00000000

Methods Mentioned

BETA
transgenic
RNA-Seq
confocal microscopy
PCR

Software Mentioned

BWA
MEGA6
DnaSP
TriAnnot
BLASTx
ABI Sequencing Analysis
EnsemblPlants
DESeq2
Ensembl
SeqMan

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