A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster.

Genetics
S B ShepardM A Muskavitch

Abstract

A dramatic example of a phenotypic interaction that involves neurogenic loci during Drosophila imaginal development is the synergistic impact of split (spl), a recessive allele of the Notch locus, and E(spl)D, a dominant gain-of-function allele of the Enhancer of split locus, on morphogenesis of the compound eye. Screens for mutations that relieve the enhancing effect of E(spl)D on spl have yielded three classes of mutations: intragenic revertants of the E(spl)D allele, extragenic suppressors that are allelic to the neurogenic gene Delta (Dl) and unlinked extragenic modifiers. Analysis of the suppression of the spl-E(spl)D interaction by various Dl alleles indicates that this modification is sensitive to the dosage of the Dl locus. This tripartite interaction illustrates the combinatorial action of N, Dl and E(spl) during imaginal development.

Citations

Oct 1, 1993·Journal of Neurobiology·J A Campos-Ortega
Jan 6, 2006·Molecular Genetics and Genomics : MGG·Takashi J FuwaKenji Matsuno
Feb 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Michael Brand, José A Campos-Ortega
Jan 1, 1993·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Kyria TietzeElisabeth Knust
Apr 1, 1995·Molecular Neurobiology·J A Campos-Ortega
Jan 1, 1994·Journal of Physiology, Paris·J A Campos-Ortega
Sep 1, 1994·Mechanisms of Development·H K HingS Artavanis-Tsakonas
Feb 1, 1992·Molecular and Cellular Biology·J D ChenV Pirrotta
Jun 19, 2009·Genesis : the Journal of Genetics and Development·Ezgi Kunttas-TatliAshok P Bidwai
Dec 17, 2009·Genesis : the Journal of Genetics and Development·Bhaskar KahaliAshok P Bidwai
Mar 1, 1990·Genes & Development·T XuS Artavanis-Tsakonas

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.