A tripeptide discriminator for stop codon recognition

FEBS Letters
Yoshikazu Nakamura, Koichi Ito

Abstract

Only recently has it been established that a tripeptide in the bacterial release factors (RFs), RF1 and RF2, is responsible for the stop codon recognition. This functional mimic of the anticodon of tRNA is referred to as a tripeptide 'anticodon' or a tripeptide discriminator. Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes.

References

Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·O MikuniY Nakamura
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·K ItoY Nakamura
Jan 1, 1996·Progress in Nucleic Acid Research and Molecular Biology·W P TateS A Mannering
Oct 18, 1996·Cell·Y NakamuraL A Isaksson
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·K ItoY Nakamura
Jul 31, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y Nakamura, K Ito
Jan 26, 2000·Nature·M Ito
Jun 1, 2000·Cell·Y NakamuraM Ehrenberg
Oct 4, 2000·Nature Structural Biology·K S WilsonY Nakamura
Nov 21, 2000·Trends in Biochemical Sciences·L L Kisselev, R H Buckingham

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Citations

Jan 29, 2008·Current Genetics·Jan KutnerMagdalena Boguta
Feb 11, 2003·Trends in Biochemical Sciences·Yoshikazu Nakamura, Koichi Ito
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrei KorostelevHarry F Noller
Jan 7, 2003·The EMBO Journal·Lev KisselevLudmila Frolova
Nov 12, 2005·Nucleic Acids Research·Petr KolosovLev Kisselev
Mar 3, 2010·Annual Review of Biophysics·Jack A Dunkle, Jamie H D Cate
May 10, 2012·Biology Direct·Martijn A HuynenSander B Nabuurs
Jul 15, 2009·Biochimica Et Biophysica Acta·Miljan Simonović, Thomas A Steitz
Jun 26, 2003·Molecular Microbiology·Cecília Maria Arraiano, Lynne Elizabeth Maquat
Aug 9, 2011·Wiley Interdisciplinary Reviews. RNA·Yoshikazu Nakamura, Koichi Ito
Aug 28, 2012·Journal of Molecular Biology·Yoshihiro Shimizu
Feb 28, 2013·The Journal of Physical Chemistry. B·Carles Acosta-SilvaAntoni Oliva
Jul 4, 2008·Nature·Martin LaurbergHarry F Noller
Mar 23, 2011·Trends in Biochemical Sciences·Bruno P Klaholz

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