A triple-probe FISH screening strategy for risk-stratified therapy of acute lymphoblastic leukaemia in low-resource settings.

Pediatric Blood & Cancer
Mayur PariharShekhar Krishnan

Abstract

Karyotyping along with a 3-probe fluorescence in situ hybridization (FISH) strategy was used to risk stratify therapy in 303 children with B-cell precursor acute lymphoblastic leukaemia. Of the 166 patients risk stratified, karyotype identified 91 (55%). FISH identified all karyotypes accurately, with the exception of hypodiploidy, and risk stratified an additional 75 patients. The frequency of ETV6-RUNX1 is lower and high hyperdiploidy, higher than reported in the west. An adapted 3-probe FISH strategy identified two patients with ETV6-ABL1 fusion who received imatinib. In limited-resource settings, a 3-probe FISH approach provides a practical approach for risk-stratified therapy in childhood ALL.

References

Aug 13, 2010·British Journal of Haematology·Christine J HarrisonUNKNOWN Biology and Diagnosis Committee of International Berlin-Frankfürt-Münster study group
Mar 1, 2014·Journal of Pediatric Hematology/oncology·Mayur PariharMammen Chandy
Sep 11, 2014·The New England Journal of Medicine·Kathryn G RobertsCharles G Mullighan
Dec 17, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Prashant TembhareP G Subramanian

❮ Previous
Next ❯

Citations

Mar 13, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Manisha AgarwalTathagata Chatterjee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.