A tripodal ruthenium-gadolinium metallostar as a potential α(v)β(3) integrin specific bimodal imaging contrast agent

Inorganic Chemistry
Peter VerwilstWim De Borggraeve

Abstract

Gd(III)-containing metallostar contrast agents are gaining increased attention, because their architecture allows for a slower tumbling rate, which, in turn, results in larger relaxivities. So far, these metallostars find possible applications as blood pool contrast agents. In this work, the first example of a tissue-selective metallostar contrast agent is described. This RGD-peptide decorated Ru(II)(Gd(III))(3)metallostar is synthesized as an α(v)β(3)-integrin specific contrast agent, with possible applications in the detection of atherosclerotic plaques and tumor angiogenesis. The contrast agent showed a relaxivity of 9.65 s(-1) mM(-1), which represents an increase of 170%, compared to a low-molecular-weight analogue, because of a decreased tumbling rate (τ(R) = 470 ps). The presence of the MLCT band (absorption 375-500 nm, emission 525-850 nm) of the central Ru(II)(Ph-Phen)(3)-based complex grants the metallostar attractive luminescent properties. The (3)MLCT emission is characterized by a quantum yield of 4.69% and a lifetime of 804 ns, which makes it an interesting candidate for time-gated luminescence imaging. The potential application as a selective MRI contrast agent for α(v)β(3)-integrin expressing tissues is shown by ...Continue Reading

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Citations

Dec 18, 2013·Chemical Reviews·Marie C HeffernThomas J Meade
Feb 13, 2016·Journal of Translational Medicine·Joji IidaCraig D Shriver
Jan 28, 2015·Chemical Society Reviews·Peter VerwilstJong Seung Kim
May 27, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Sophie CarronJohn A Capobianco
May 15, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Graeme J StasiukMarinella Mazzanti
Feb 8, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jacques LuxAdah Almutairi
May 1, 2017·ChemPlusChem·Séverine LechevallierMarc Verelst
Feb 22, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Stephen J ButlerDmitry S Yufit
Jan 18, 2014·Journal of the American Chemical Society·Evan R TrivediVincent L Pecoraro
Jul 18, 2020·Inorganic Chemistry·Hannah L PerryJames D E T Wilton-Ely

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