A trivalent vaccine candidate against hepatitis E virus, norovirus, and astrovirus

Vaccine
Ming XiaMing Tan

Abstract

Hepatitis E virus (HEV), norovirus (NoV), and astrovirus (AstV) are enterically-transmitted viral pathogens causing epidemic or endemic hepatitis (HEV) and gastroenteritis (NoV and AstV) respectively in humans, leading to significant morbidity and mortality worldwide. While a recombinant subunit vaccine against HEVs is available in China, there is no commercial vaccine or antiviral against NoV or AstV. We report here our development of a trivalent vaccine against the three viral pathogens through our new polymer vaccine technology. All HEV, NoV, and AstV are non-enveloped RNA viruses covered by a protein capsid, featuring surface protruding (P) proteins that are responsible for virus-host interaction. These dimeric P proteins elicit neutralizing antibody and are good targets for subunit vaccine development. The trivalent subunit vaccine was developed by fusion of the dimeric P domains of the three viruses together that formed tetramers. This trivalent vaccine elicited significantly higher antibody responses in mice against all three P domains than those induced by a mixture of the three free P domains (mixed vaccine). Furthermore, the post-immune antisera of the trivalent vaccine showed significantly higher neutralizing titers ...Continue Reading

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Citations

Sep 21, 2016·Human Vaccines & Immunotherapeutics·Ming Tan, Xi Jiang
Nov 16, 2017·BMC Infectious Diseases·Freddy Jun Xian NeoChing Ging Ng
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Jun 3, 2021·Viruses·Matthew Ykema, Yizhi J Tao
Sep 9, 2021·Human Vaccines & Immunotherapeutics·Na WeiJianqiang Li

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